first and second drafts prepared by staff members at the Fraunhofer Institute of Toxicology and Aerosol Research, Hanover, Germany, under the coordination of R.F. Hertel, G. Rosner, and J. Kielhorn, in cooperation with E. Menichini, P.L. Grover, and J. Blok ; P. Muller, R. Schoeny and T.L. Mumford prepared and revised the drafts of appendix I