The purpose of this narrative inquiry study was to thoroughly examine the lived experiences of African American female entrepreneurs with PhDs. Ten women were chosen for this study, and they candidly shared their academic and entrepreneurial experiences, challenges, and definitions of success. Critical race feminism was the theoretical lens used in this study. This narrative study consisted of in-depth semi structured interviews. The findings revealed that American African women have distinct definitions of success. Among the research participants, five salient themes emerged from the data. These themes include: (a) family, (b) early emphasis on education, (c) faith, (d) meaningful mentorship experiences, and (e) entrepreneurial spirit. Business success was defined as helping others and customer satisfaction, having personal fulfillment, and achieving monetary gain. In addition, the intersection of race and gender has been shown to play a major part in their experiences. This study revealed that Black women entrepreneurs with PhDs have a unique definition of business success and are directly and indirectly impacted by the intersection of race and gender. Despite their academic credentials, personal and professional success, and socioeconomic status, these Dr. Sistaphrenuers are not immune to the tinge of racial and gender bias. These women carved their own path and created and defined success on their own terms.