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Videos, Slides, Films
Postsynaptic scaffold proteins in health and disease
- Author / Creator
- Available as
- Online
Details
- Creator
- Jonathan Hanley
- Format
- Videos, Slides, Films
- Language
- English
- Publication
-
- London : Henry Stewart Talks, 2014
- Physical Details
-
- 1 videorecording (47 mins., 49 sec.) : sound, color
- video file
- Animated audio-visual presentation with synchronized narration.
- Title from title frames.
- Contents: Multi-domain structure of scaffold proteins allows multiple protein-protein interactions -- They localise important signaling proteins close to neurotransmitter receptor complexes -- Scaffold proteins at excitatory synapses underpin synaptic plasticity by regulating AMPA receptor trafficking and dendritic spine morphology -- Mutations in scaffold proteins underlie neuropsychiatric diseases such as autism and schizophrenia -- Other diseases including Alzheimers and stroke also involve mechanisms incorporating postsynaptic scaffold proteins
Subjects
- Brain -- Diseases -- Pathophysiology.
- Neuronal plasticity.
- Protein-protein interactions.
- Synapses -- Physiology.
- Synaptic transmission -- Physiology.
- Brain Diseases -- physiopathology.
Medical Subject Heading
- Nerve Tissue Proteins -- metabolism.
Medical Subject Heading
- Neuronal Plasticity -- physiology.
Medical Subject Heading
- Synapses -- physiology.
Medical Subject Heading
- Synaptic Transmission -- physiology.
Medical Subject Heading