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Lung biology and lung disease
- Author / Creator
- Available as
- Online
Details
- Creator
- John S. Torday
- Format
- Videos, Slides, Films
- Language
- English
- Publication
-
- London : Henry Stewart Talks, 2011
- Physical Details
-
- 1 videorecording (53 min., 10 sec.) : sound, color
- video file
- Retrieved April 13, 2024, from https://hstalks.com/bs/157/.
- Introduction -- Biology as a maze -- Key points of lecture -- Evolution of limbs -- Lung disease as simplification -- Lung development results in increased complexity -- Haeckle's insight to evolution -- Lung biologic continuum -- Evolution as a mobius strip (1) -- Cellular cooperativity of multicellular organisms -- Cell cooperativity in evolution -- Lung evolution -- Photomicrograph of alveoli -- Surfactant phylogeny -- Reptile lung phenotypes -- Plasticity of alveolization -- From simple experiments..... -- Cellular lung homeostasis -- Cellular cooperativity -- Image of lipofibroblast -- Discovery of neutral lipid trafficking -- Paradoxes in lipid trafficking -- Paradoxes solved (1) -- Paradoxes solved (2) -- Paradoxes solved (3) -- Gaining insight to the evolution of the lung -- Alveolar homeostasis -- Parathyroid hormone-related protein -- Stretch stimulates PTHrP -- Lung evolution due to PTHrP signaling -- Rotating wall vessel -- Effect of zero G on PTHrP (1) -- STS-58 "rats in space" -- Effect of zero G on PTHrP (2) -- PTHrP knock out characteristics -- PTHrP knock out histology -- How PTHrP signaling 'drives' lung evolution -- Phylogeny, ontogeny of lung (1) -- Phylogeny, ontogeny of lung (2) -- Phylogenetic effect of PTHrP -- Selection for PTHrP signaling -- Cellular lung phylogeny -- Surface area versus septal thickness -- PTHrP signaling/lung evolution -- Wnt versus PTHrP in lung evolution -- PTHrP signaling/alveolar size -- PTHrP causes septal thinning -- Leptin stimulates collagen -- Leptin stimulates collagen - DATA -- Signaling in lung evolution -- Evolutionary selection pressure -- Oxygen/stretch selection pressure -- Experimental lung evolution -- Emergent and contingent -- Merging the different factors -- How genes shuffle to generate novel phenotypes -- Lung biology and treatment -- PTHrP and lung evolution-schema -- Schema for lung evolution -- Evolution as a mobius strip (2) -- References