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Videos, Slides, Films
Ca2+, the endoplasmic reticulum and cardiac pathology
- Author / Creator
- Available as
- Online
Details
- Creator
- Marek Michalak
- Format
- Videos, Slides, Films
- Language
- English
- Publication
-
- London : Henry Stewart Talks, 2012
- Physical Details
-
- 1 videorecording (27 min.) : sound, color
- video file
- Retrieved April 13, 2024, from https://hstalks.com/bs/2409/.
- Introduction -- The endoplasmic reticulum (1) -- The endoplasmic reticulum (2) -- Endoplasmic reticulum luminal environment -- The sarcoplasmic reticulum -- Calcium and cardiac pathology -- Calreticulin deficient embryos -- Incomplete development of septum -- Agonist calcium release in mutant cells -- Calcium dependent transcription factors -- Impact of calreticulin on Ca2+ homeostasis -- Calreticulin deficiency loss of function -- Embryonic stem cells studies -- ES cell derived embryoid body -- Isolated ES cell-derived cardiomyocytes -- Differentiation without calreticulin -- Incorrectly formed sarcomeric structures -- Important domains -- Calcium and cardiogenesis -- Calreticulin is critical for cardiogenesis -- Impact of increased level of calreticulin -- Reduced SOCE in calreticulin expressing cells -- Calreticulin gain of function -- Gain of function and disease -- Embryonic stem cells and gain of function -- Contractile function -- MHC promoter activity -- Pacemaker cells -- The cardiac conductive system -- Tamoxifen inducible calreticulin mice -- Dilated cardiomyopathy and fibrosis -- Dilated cardiomyopathy and heart failure -- Cardiac hypertrophy genes -- Membrane associated proteins -- Summary of talk -- Take home message