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P53 family : function and molecular mechanisms
- Author / Creator
- Available as
- Online
Details
- Creator
- Gerry Melino
- Format
- Videos, Slides, Films
- Language
- English
- Publication
-
- London : Henry Stewart Talks Ltd, 2007
- Physical Details
-
- 1 videorecording (46 min., 29 sec.)
- video file
- Retrieved April 11, 2024, from https://hstalks.com/bs/292/.
- Introduction -- Odysseus Is Tempted by the Sirens -- Role and importance of p53 -- The p53 family (1) -- The p53 family (2) -- The p53 gene -- p73-/- show neural defects -- p73 regulates neural differentiation -- p73 in immunity (1) -- p73 in immunity (2) -- p73 in immunity and cancer -- Incidence of p73 alterations in cancer -- Involvement of p73 in DNA damage response -- Cell cycle arrest and apoptosis by p53 and TAp73 -- TAp73 induces apoptosis, while DNp73 inhibits it -- The identification of p73 pathway -- p73 post-translational modifications -- The various proteins involved in p73 pathway -- Interacting proteins: WW proteins -- Role of chemo / radiotherapy in p73 activation (1) -- Example: transactivation of CD95 gene (1) -- p73 synergize with chemotherapy -- p73 in hepatoma cells -- Example: transactivation of CD95 gene (2) -- Inactivation of p73 in cancer -- Interaction between p53 and p63/p73 -- The life of a cell -- Underground map of cell city -- Suicide bomb attack to cancer city -- Role of chemo / radiotherapy in p73 activation (2) -- TAp73 degradation (1) -- TAp73 degradation (2) -- Degradation of ITCH and DNp73 in DNA damage -- Can we control p73 protein levels? -- Role of PML in stabilizing TAp73 protein -- Conclusion of p73 degradation -- Interacting proteins:Bub1, Bub3 -- p73 in cell cycle control -- Summary: p73 -- The p53 family (3) -- Some effects of p63 -- TAp63 induces cell cycle arrest and apoptosis -- p63-induced apoptosis and p63 degradation (1) -- p63-induced apoptosis and p63 degradation (2) -- Role of p63 in epidermis and human diseases (1) -- Role of p63 in epidermis and human diseases (2) -- Vibrissae -- Tooth development and p63 (1) -- Tooth development and p63 (2) -- Tooth development and p63 (3) -- Formation of the epidermis (1) -- Formation of the epidermis (2) -- What is the function of p63? -- p63 Transcriptional targets -- Summary: p63 -- Evolution of the p53 family -- Timescale of p63/p73 research