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Type I interferon system and viruses
- Author / Creator
- Available as
- Online
- Summary
-
Audio-visual presentation : Type I IFN, a cytokine with antiviral activity ; General mechanism of action of type I IFN ; The IFN pathway;Induction of IFN and inhibition by viruses ; Cellular sensor...
Audio-visual presentation : Type I IFN, a cytokine with antiviral activity ; General mechanism of action of type I IFN ; The IFN pathway;Induction of IFN and inhibition by viruses ; Cellular sensors of viral products ; Signaling pathway leading to type IFN production ; Viral products inhibit this pathway at different levels ; IFN signaling ; The Jak-STAT pathway ; IFN stimulated genes (ISGs) ; The IFN inducible Mx gene ; The PKR pathway and its inhibition by viruses ; The OAS/RNaseL pathway and its inhibition by viruses ; Other ISGs ; Viral inhibitors of cellular gene expression ; The IFN system and its inhibition by viruses: a continuously evolving battle ; Biological role of viral IFN antagonism ; Therapeutic and prophylactic applications of current knowledge on viral IFN antagonism.
Details
- Creator
- Adolfo García-Sastre
- Format
- Videos, Slides, Films
- Language
- English
- Publication
-
- London : Henry Stewart Talks Ltd, 2018
- Physical Details
-
- 1 videorecording (35 min., 49 sec.)
- video file
- Retrieved April 15, 2024, from https://hstalks.com/bs/356/.
- Introduction -- Interferon, the oldest known cytokine -- Type I interferon mechanism of action -- The IFN pathway -- Viral inhibitors of IFN induction -- The IFN pathway - inhibition of IFN induction -- Detection of viruses by the host -- Detection of viruses by the host - RNA viruses -- Activation and inhibition of RIG-I -- Detection of viruses by the host - DNA viruses -- The IFN pathway - inhibition of IFN signaling -- IFN-beta signaling pathway -- Viral inhibitors of IFN signaling -- How viruses inhibit IFN signaling -- The IFN pathway - anti viral gene products -- Mx pathway -- PKR pathway -- 2-5(A) synthetases (OAS) pathway -- Genes with antiviral activity - summary -- Other IFN-induced antiviral pathways -- Viral Inhibitors of cellular gene expression -- Coordination in vivo -- Role of viral IFN antagonists -- Uses of Viruses with debilitated IFN antagonists -- Thank you