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The kinetochore as a target for the development of mitosis specific anti-cancer drugs
- Author / Creator
- Available as
- Online
Details
- Creator
- Dr. Tim Yen - Fox Chase Cancer Center, Philadelphia, USA
- Format
- Videos, Slides, Films
- Language
- English
- Publication
-
- London, England : Henry Stewart Talks Ltd, 2009
- Physical Details
-
- 1 videorecording (48 mins., 16 sec.) : sound, color
- video file
- Retrieved April 10, 2024, from https://hstalks.com/bs/1273/.
- Introduction -- Talk topics -- The kinetochore -- Molecular composition of the human kinetochore -- Kinetochore proteins assemble in a temporal order -- CENP-F localization at different stages of G2 -- Defining temporal orders of assembly -- FRAP studies and kinetochore -- Turnover dynamics of kinetochore proteins -- What is the kinetochore? -- CENP-E: a kinesin like motor -- CENP-E exhibits a dynamic localization pattern -- CENP-E is essential for microtubule attachment -- The HEC1/Ndc80 complex -- Different phenotypes for various depletions -- Three steps of the mitotic checkpoint pathway -- Checkpoint proteins localize to kinetochores -- The kinetochore and its relation to cancer -- The mitotic checkpoint and cancer -- Mitotic checkpoint genes are essential -- Mitotic checkpoints and genome instability -- The kinetochore as a mitosis specific target -- Inhibitors of mitosis -- Ansamycins are inhibitors of Hsp90 -- 17-AAG blocks assembly of CENP-H and I -- Histone deacetylase inhibitors -- HDI delays human tumor cell lines in mitosis -- HDI interferes protein assembly onto kinetochore -- Not all kinetochore localized proteins are affected -- The depletion is not a result of degradation -- FTI's block farnesylation of proteins -- FTI-2153 alters the localization of CENP-F -- Effect of FTI on lung cancer cells -- Inhibitors of kinetochore/spindle proteins -- Kinase inhibitors-Aurora and Plk1 -- Polo kinases - Plk1-4 -- Pros and cons of targeting the mitotic checkpoint -- Linking chromosome missegregation to cell death -- The checkpoint and apoptosis pathways -- Hela cells depleted of hNuf2 accumulate in mitosis -- Timelapse videos of mitotically arrested cells -- Hela cells blocked in mitosis undergo apoptosis -- Patient response -- Conclusions and future directions