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Videos, Slides, Films
NK cell signaling to cytotoxicity. Parts II & III
- Author / Creator
- Available as
- Online
Details
- Creator
- Dan Billadeau
- Format
- Videos, Slides, Films
- Language
- English
- Publication
-
- London : Henry Stewart Talks, 2010
- Physical Details
-
- 1 videorecording (38 min., 57 sec.) : sound, color
- video file
- Retrieved April 9, 2024, from https://hstalks.com/bs/1836/.
- Introduction -- Part II: the NKG2D-DAP10 signaling complex -- The human NKG2D-DAP10 complex -- Importance of YINM motif in DAP10 signaling -- Coupling to p85 and Grb2/Vav -- Grb2: signaling and activation -- PI3K is required for NKG2D-mediated killing -- CrkL regulates conjugate formation -- Rap1 activation by NKG2D -- JNK1 activation by NKG2D -- Summary of part II -- Part III: inhibitory receptor signaling -- iKIR crosslinking leads SHP1 recruitment -- SHP1 binds directly to the ITIM motif -- iKIR engagement blocks signaling -- Catalytically-inactive SHP1 leads to cell death -- What are the targets of SHP1? -- Vav1 is a target of SHP1 -- Summary of part III -- Acknowledgements