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Monocyte/macrophages in innate immunity
- Author / Creator
- Available as
- Online
Details
- Creator
- Siamon Gordon
- Format
- Videos, Slides, Films
- Language
- English
- Publication
-
- London : Henry Stewart Talks Ltd, 2009
- Physical Details
-
- 1 streaming video file (73 min.) : digital, mono, SWF file, sound, color
- video file
- Retrieved April 16, 2024, from https://hstalks.com/bs/1287/.
- Introduction -- Significant figures in macrophage research -- Human diseases of innate immunity -- Macrophages in innate immunity -- Talk outline -- Differentiation and distribution of macrophages -- The EGF-TM7 family -- Macrophages remodel tissues in development -- Kupffer cells F4/80+ -- Resident tissue macrophages' microheterogeneity -- Differentiation of monocytes -- F4/80+ Langerhans cell in normal skin -- Differentiation of microglia -- Trophic interaction: haematopoiesis -- Haematopoietic stroma -- F4/80 in red pulp spleen -- Sialoadhesin in marginal zone of spleen -- Marginal zone -- Monocyte recruitment -- Experimental models: sterile mouse peritonitis -- BCG granulomata -- Lysozyme expression in activated macrophages -- Monocyte heterogeneity and recruitment -- Differential activation of macrophages -- Phagocytosis of apoptotic thymocyte -- Antibody coated erythrocytes (EIgG) -- Phagocytic pathway -- APC pattern recognition receptors -- APC receptors -- Sensors of pattern recognition -- Macrophage receptors -- Macrophage interactions -- Dectin-1 -- Dectin-1 recognises beta 1-3/6 linked glucans -- Zymosan induced TNF-alpha production -- Dectin-1 tail is required for cytokine secretion -- Dectin-1 ITAM like motif is required for ingestion -- Dectin-1 collaborates with TLR in signalling -- Fungal walls are rich in beta glucan -- Uptake of C. albicans by macrophages -- Candida infection in dectin-1-deficient mice -- Mannose receptor (MR): overview -- Mannose receptor -- Reagents used in search for MR ligands -- CRD4-7Fc recognises ligands in secretory organs -- Ligands for the cysteine-rich domain of the MR -- The sMR-mediated Ag delivery hypothesis -- A subset of Met macrophages express CR-ligands -- CR-ligand+ cells migrate in response to LPS -- LPS increases the humoral response -- Scavenger receptors -- Scavenger receptor A -- Meningococcal septicaemia, haemorrhagic rash -- Neisseria meningitidis (NM) -- SR-A and Neisseria meningitidis -- Uptake of NM is uncoupled from TNF production -- Scavenger receptor A and NM -- SR-A protects against NM -- MARCO in a marker of activated macrophage -- Binding of NM -- Role of NM, INF-gamma in MARCO expression -- Receptor collaboration -- Plasma membrane in macrophage functions -- EGF-TM7 family functions -- Activatory and inhibitory receptor pairs -- Macrophage fusion -- Quantitation of macrophage fusion -- Isolation of antibodies -- Model of IL-4 induced macrophage fusion -- Functional significance of macrophage fusion -- Summary: macrophages in innate immunity -- Thanks -- References