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Videos, Slides, Films
Adapting proteostasis to ameliorate aggregation-associated amyloid diseases
- Author / Creator
- Available as
- Online
Details
- Creator
- Jeffery W. Kelly
- Format
- Videos, Slides, Films
- Language
- English
- Publication
-
- London : Henry Stewart Talks, 2018
- Physical Details
-
- 1 online resource (1 streaming video file (49 min.)) : sound, color
- video file
- Animated audio-visual presentation with synchronized narration.
- Title from title frames.
- Contents: Protein folding, misfolding, aggregation -- The proteostasis network and its regulation -- Gain and loss of function diseases -- The transthyretin (TTR) amyloidosis -- Kinetic stabilizers & clinical trial results -- Tafamidis & Diflunisal: evidence for the amyloid hypothesis -- Improving protein misfolding/aggregation diseases -- The unfolded protein response (UPR) and its arm-selective activators -- ATF6 activation & reduction of TTR mutant -- Clinical trials in amyloidosis with cardiac involvement
Subjects
- Amyloidosis -- Treatment.
- Clinical trials.
- Protein folding.
- Proteins -- Metabolism -- Disorders.
- Activating Transcription Factor 6 -- metabolism.
Medical Subject Heading
- Amyloid -- metabolism.
Medical Subject Heading
- Amyloidosis -- drug therapy.
Medical Subject Heading
- Clinical Trials as Topic.
Medical Subject Heading
- Diflunisal.
Medical Subject Heading
- Prealbumin.
Medical Subject Heading
- Protein Aggregates -- drug effects.
Medical Subject Heading
- Proteostasis.
Medical Subject Heading
- Unfolded Protein Response -- drug effects.
Medical Subject Heading