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Polyadenylation of mRNA precursors : mechanism, regulation and connections with other cellular processes
- Author / Creator
- Available as
- Online
Details
- Creator
- James L. Manley
- Format
- Videos, Slides, Films
- Language
- English
- Publication
-
- London : Henry Stewart Talks Ltd, 2016
- Physical Details
-
- 1 videorecording (47 min., 12 sec.)
- video file
- Retrieved April 12, 2024, from https://hstalks.com/bs/627/.
- Introduction -- Polyadenylation of mRNA precursors -- The polyadenylation machinery -- Complexity in PAP -- Hyperphosphorylation inhibits PAP activity -- Gld-2 polyadenylation of maternal mRNAs -- The polyadenylation machinery - CPSF -- CPSF-73 is the 3' endonuclease -- No CPSF-73 in cytoplasmic polyadenylation -- The polyadenylation machinery - CstF -- CstF protein interactions -- Regulation of expression by alternative polyA site -- The RNAP II CTD contacts multiple factors -- CTD stimulates 3' cleavage in vitro -- CPSF links transcription and 3' end formation -- CstF-64 crosslinks to promoter -- Polyadenylation and other cellular processes -- CstF-50 -- BRCA1 -- BARD1--BRCA-Associated RING Domain Protein -- Why does BARD1 Inhibit 3' processing? -- DNA damage inhibits 3' processing -- How does BARD1 Inhibit 3' processing? -- BRCA1/BARD1 targets RNAP IIo for ubiquitination -- Factors of the mRNA 3' end formation machinery -- References