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Regulation of type 2 immunity by basophils
- Author / Creator
- Available as
- Online
Details
- Creator
- David Voehringer
- Format
- Videos, Slides, Films
- Language
- English
- Publication
-
- London : Henry Stewart Talks Ltd, 2012
- Physical Details
-
- 1 streaming video file (32 min.) : color, sound
- video file
- Retrieved April 13, 2024, from https://hstalks.com/bs/2288/.
- Introduction -- Outline of the presentation -- Type 1 vs. Type 2 immunity -- Type 2 immunity - a double-edged sword -- Development of a type 2 immune response -- Discovery of innate type 2 effector cells -- Basophils, mast cells and eosinophils -- Developmental relationship -- Detection of basophils by CD49b/IgE staining -- Nippostrongylus brasiliensis infection -- N. brasiliensis infected lung -- N. brasiliensis infected small intestine -- Analysis of basophil turnover in vivo -- Activating receptors on basophils -- Activation of basophils by IgE -- Cytokine instruction of basophils -- Basophil effector functions -- Generation & analysis of basophil-deficient mice -- Mast cell protease 8 is expressed in basophils -- Deletion of basophils in Mcpt8Cre mice -- Mast cells are not deleted in Mcpt8Cre mice -- Effector function of basophils -- Are basophils required for Th2 polarization? -- DCs or basophils for Th2 polarization? (1) -- Generation of DC-deficient mice -- DCs or basophils for Th2 polarization? (2) -- DCs are required for Th2 polarization -- Role of innate IL-4 for Th2 polarization -- Innate IL-4/IL-13 regulates Th2 accumulation -- Basophils in anaphylactic responses -- IgG1-mediated systemic anaphylaxis -- Basophils aren't required for anaphylaxis -- Basophils in chronic allergic inflammation of skin -- Basophils are required for allergic inflammation -- Basophil response against helminths and ticks -- Primary response to N. brasiliensis -- Expulsion kinetics of N. brasiliensis -- Protective immunity against N. brasiliensis -- Basophils during secondary infection -- Protective immunity against ticks -- Summary -- Acknowledgements