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Advances in cancer research. Volume 45
- Available as
- Online
- Summary
-
ADVANCES IN CANCER RESEARCH, VOLUME 45
Details
- Creator
- edited by George Klein
- Format
- Books
- Language
- English
- Contributors
- Publication
-
- New York : Academic Press, 1985
- Physical Details
-
- 1 online resource (335 p.)
- ISBNs
- 1281451177, 9786611451172, 0080562272, 0120066459
- OCLC
- ocn476164599
- Description based upon print version of record.
- Includes bibliographical references and index.
- English
- Front Cover; Advances in Cancer Research, Volume 45; Copyright Page; Contents; Contributors to Volume 45; Chapter 1. Down-Regulation of the Antitumor Immune Response; I. Introduction; II. Tumor Immunogenicity; III. Concomitant Immunity as the Unsuccessful Response to Tumor Growth; IV. Evidence That Tumor Growth Induces Suppressor T Cells; V. Evidence That the Generation of Effector T Cells Precedes the Generation of Suppressor T Cells; VI. Evaluation of the Evidence That Ly 1+,2-Suppressor T Cells Down-Regulate the Generation of Ly-, 2+ T Cell That Mediated Concomitant Immunity
- VII. Tumor-Induced Immunosuppression as the Explanation of Escape from ImmunityVIII. Suppression of Antitumor Immunity as an Example of Transplantation Tolerance; IX. Immunotherapeutic Significance of the Generation and Subsequent Decay of Concomitant Immunity; X. Conclusion; References; Chapter 2. Cellular Aspects of DNA Repair; I. Introduction; II. Recognition of Damage by Cells; III. In Vivo Aspects of Excision Repair; IV. Effects of the Local Environment on Reaction and Repair; V. Poly(ADP-Ribose); VI. The Repair of O-Alkylated Sites; VII. Adaptive Response
- VIII. Bypass of Lesions and Its ConsequenceIX. Error-Prone Repair and Mutation; X. Biological Role of Repair; XI. Appendix; References; Chapter 3. The Blym Oncogenes; I. Definitions and Significance; II. Oncogenes in Bursal Lymphomas; III. Blym-1 Oncogenes in Human Burkitt's Lymphomas; IV. Issues for Continued Investigation; References; Chapter 4. Retrovirus-Induced Acquired Immunodeficiencies; I. Introduction; III. lrnrnunodepressive Changes in Retrovirus-Infected Animals; IV. Functional Alterations of Immunocompetent Cells in Retrovirus-Infected Animals
- V. Mechanisms Leading to Immunocompetent Cell Alteration in Retrovirus InfectionsVI. Role of Retrovirus-Induced Immunodeficiency in Pathogenesis; VII. The Retroviral Etiology of AIDS; VIII. Summary and Perspectives; References; Chapter 5. The Molecular Action of Platelet-Derived Growth Factor; I. Introduction; II. The Biology of Platelet-Derived Growth Factor; III. Biochemistry of PDGF; IV. The Sis/PDGF Gene; V. The Biology of the Sis Oncogene; VI. The PDGF Receptor; VII. Metabolic Effects of PDGF; VIII. PDGF Modulation of the EGF Receptor; IX. Effect of PDGF on Ion Fluxes
- X. PDGF-Stimulated Protein PhosphorylationsXI. Regulation of Gene Expression by PDGF; XII . Conclusion; References; Chapter 6. Trichothecenes, Zearalenone, and Other Carcinogenic Metabolites of Fusarium and Related Microfungi; I. Introduction; II. Secondary Metabolites of Fusaria; III. Epidemiological Considerations; IV. Occurrence and Pathological Effects of T-2 Toxin; V. Diacetoxyscirpenol (Anguidine, NSC-141537); VI. The Antileukemic Baccharinoids and Other Macrocyclic Trichothecenes; VII. Metabolism of T-2 Toxin; VIII. Effects of T-2 Toxin and Related Trichothecenes on the Immune System
- IX. Detection and Estimation of Trichothecenes