Front Cover; Advances in Cancer Research, Volume 21; Copyright Page; Contents; Contributors to Volume 21; Chapter 1. Lung Tumors in Mice: Application to Carcinogenesis Bioassay; I. Introduction; II. Frequency and Distribution; III. Morphology; IV. Histogenesis; V. Growth and Transplantation; VI. Biochemical Characteristics; VII. Host Factors; VIII. Environmental Influences; IX. Virus Aspects; X. Lung Tumor Induction with Chemicals; XI. Lung Tumor Induction with Other Agents; XII. Lung Tumor Bioassay; XIII. Explants and Embryos; XIV. Conclusions; References
Chapter 2. Cell Death in Normal and Malignant TissuesI. Introduction; II. Cell Loss in Embryogenesis; III. Transmission Electron Microscopy; IV. Microcinematography; V. Scanning Electron Microscopy; VI. Chromosome Aberrations as a Cause of Cell Loss; VII. Identification of Dead Cells in Vitro; VIII. Assessment of Tumor Cell Death in Vioo; IX. The Blood Supply of Tumors and Tumor Cell Necrosis; X. Immune Elimination of Cancer Cells; XI. Phagocytosis and Autolysis; XII. Tumor Cell Loss by Differentiation; XIII. Cell Loss in Experimental Tumors; XIV. Cell Loss in Human Tumors
XV. Cell Loss and the Treatment of TumorsAddendum: Mathematical Treatment of Cell Loss in Tumors; References; Chapter 3. The Histocompatibility-Linked Immune Response Genes; I. Immune Responses Controlled by Histocompatibility-Linked lr Genes. Species Distribution; II. The Mapping of Mouse H-Linked lr Genes; III. Relationship of H-Linked lr Genes to Immunoglobulin Structural Genes; IV. The Cell Type Where Histocompatibility-Linked lr Genes are Expressed; V. The Demonstration of Suppressor T Cells Specific for GAT10 in Genetic Nonresponder Mice
VI. The Role of Histocompatibility Gene Products in T-B Cell InteractionsVII. Identification of l Region Gene Products; VIII. Relationship of Histocompatibility Gene Products to Each Other in Nature and Function; IX. Function of Products of H-Linked lr Genes and of Other l Region Gene Products: Relationship of These Products to Activation of Immunocompetent Cells; X. The Histocompatibility-Linked lr Genes and Disease; References; Chapter 4. Horizontally and Vertically Transmitted Oncornaviruses of Cats; I. Introduction; II. Characteristics of Feline Oncornaviruses
III. Antigenic Structure and Serologic DetectionIV. Virus-Host Cell Relationships; V. Cell Surface Antigens Induced by Feline Oncornaviruses; VI. Experimental Induction of Tumors with Feline Oncrnaviruses; VII. Immune Response to Experimental Infections; VIII. Virus Transmission and Natural History of Feline Leukemia; IX. Comparison of Feline Oncornavirus Infectivity Patterns to Those of Other Oncogenic or Potentially Oncogenic Viruses; X. Public Health Significance of Feline Oncornaviruses; XI. Summary and Conclusions; References
Chapter 5. Epithelial Cells: Growth in Culture of Normal and Neoplastic Forms