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Bone cell biomechanics, mechanobiology and bone diseases
- Available as
- Online
Details
- Creator
- Airong Qian and Lifang Hu, editors
- Format
- Books
- Language
- English
- Contributors
- Publication
-
- 1st ed
- London, England : Academic Press, [2024]
- ©2024
- Physical Details
-
- 1 online resource (422 pages)
- ISBNs
- 9780323994842, 0323994849, 9780323961233
- Includes bibliographical references and index.
- Intro -- Bone Cell Biomechanics, Mechanobiology, and Bone Diseases -- Copyright -- Dedication -- Contents -- Contributors -- Preface -- Acknowledgments -- Part I: Basic knowledge and research methods -- Chapter 1: Basic knowledge and research methods -- 1.1. Introduction -- 1.2. Bone structure and its cellular component -- 1.2.1. Bone matrix -- 1.2.2. Bone marrow -- 1.2.3. Periosteum -- 1.2.4. Blood vessel, lymphatic vessel, and nerve innervation of bone -- 1.2.4.1. Blood vessel of the bone -- 1.2.4.2. Lymphatic vessel of bone -- 1.2.4.3. Nerve innervation of bone -- 1.2.5. Cell components -- 1.2.5.1. Bone marrow mesenchymal stem cells -- 1.2.5.2. Preosteoblasts -- 1.2.5.3. Osteoblasts -- 1.2.5.4. Osteocytes -- 1.2.5.5. Osteoclasts -- 1.3. Cartilage structure and its cellular component -- 1.3.1. Cartilage stroma -- 1.3.1.1. Chondrocytes -- 1.3.1.2. Perichondrium -- 1.3.1.3. Chondrogenesis, growth, and degeneration -- 1.3.2. Articular cartilage -- 1.3.2.1. The structure and function of articular cartilage -- 1.3.2.2. Nutrition of the articular cartilage -- 1.3.2.3. Degeneration and repair of articular cartilage -- 1.4. Bone mechanobiology -- 1.4.1. Physiological response of bone under mechanical stimulation -- 1.4.2. Physiological response of cartilage under mechanical stimulation -- 1.5. Conclusion and perspectives -- Acknowledgments -- References -- Chapter 2: Methods and models of bone cell mechanobiology -- 2.1. Introduction -- 2.2. Methods and models of bone cell mechanobiology study in vitro -- 2.2.1. Fluid shear stress (FSS) in bone cell mechanobiology -- 2.2.2. Mechanical stretch in bone cell mechanobiology -- 2.2.3. Hydrostatic compressive force in bone cell mechanobiology -- 2.2.4. Vibration in bone cell mechanobiology -- 2.2.5. Mechanical unloading microgravity in bone cell mechanobiology -- 2.2.5.1. Superconducting magnet
- 2.2.5.2. Clinostat -- 2.2.5.3. Random position machine (RPM) -- 2.2.6. Hydrogel stiffness in bone cell mechanobiology -- 2.3. Methods and models of bone cell mechanobiology study in vivo -- 2.3.1. Three-point bending -- 2.3.2. Vibration -- 2.3.3. Exercise -- 2.3.3.1. Treadmill -- 2.3.3.2. Swimming -- 2.3.4. Hindlimb unloading (HLU) -- 2.3.5. Immobilization -- 2.3.6. Bedrest -- 2.4. Conclusion and perspectives -- Acknowledgments -- References -- Chapter 3: The whole bone mechanical properties and modeling study -- 3.1. Introduction -- 3.2. Mechanical properties of cortical bone -- 3.2.1. Basic variables and values -- 3.2.2. Strength of cortical bone -- 3.2.3. Youngs modulus/modulus of elasticity -- 3.2.4. Micro and nanoscale property of cortical bone -- 3.3. Mechanical property of trabecular bone -- 3.3.1. Trabecular bone structure and mechanical property -- 3.3.2. Strength of trabecular bone -- 3.3.3. Youngs modulus of trabecular bone -- 3.3.4. Micromechanical property and structure of trabecular tissue -- 3.4. Three-dimensional bone models and techniques in biomechanics -- 3.5. Finite element analysis (FEM) for bone analysis -- 3.5.1. Meshing -- 3.5.2. Boundary condition -- 3.5.3. Boundary condition and mesh -- 3.6. Methods for biomimetic study -- 3.6.1. Biomimetics -- 3.6.2. Multiscale modeling -- 3.6.3. Homogenization -- 3.6.4. Top-down method -- 3.6.5. Bottom-up method -- 3.7. Development of representative volume element -- 3.7.1. Honeycomb composite -- 3.7.1.1. Honeycomb-swashplate model -- 3.7.1.2. Spherical honeycomb -- 3.7.2. Nacre -- 3.7.3. Euplectella aspergillum (sea sponge) -- 3.7.3.1. Stiff walled model -- 3.7.3.2. Cubic lattice -- 3.7.4. Spider silk fiber -- 3.7.5. Comparison of biomimetic structures -- 3.8. Modeling and fracture analysis of bone and applications -- 3.9. Femur bone modeling and meshing
- 3.10. Conclusion and perspectives -- Acknowledgments -- References -- Part II: Bone cell mechanobiology -- Chapter 4: Mechanobiology of bone marrow mesenchymal stem cells (BM-MSCs) -- 4.1. Introduction -- 4.2. Bone marrow mesenchymal stem cells (BM-MSCs) -- 4.2.1. BM-MSCs characteristics -- 4.2.2. BM-MSCs function -- 4.3. Mechanical stimulation of BM-MSCs -- 4.3.1. The effect of mechanical loading on differentiation of BM-MSCs -- 4.3.2. The effect of mechanical unloading on differentiation of BM-MSCs -- 4.4. Mechanism of BM-MSCs mechanotransduction -- 4.4.1. Extracellular matrix-integrin-cytoskeleton system -- 4.4.2. Ion channel -- 4.4.3. Primary cilia -- 4.4.4. Signaling pathways -- 4.5. Conclusion and perspectives -- Acknowledgments -- References -- Chapter 5: Mechanobiology of osteoblast -- 5.1. Introduction -- 5.2. Osteoblast -- 5.2.1. Osteoblast characteristics -- 5.2.2. Osteoblast function -- 5.3. Mechanical stimulation of osteoblast -- 5.3.1. The effect of mechanical loading on osteoblast -- 5.3.2. The effect of mechanical unloading on osteoblast -- 5.4. Mechanism of osteoblast mechanotransduction -- 5.4.1. Mechanical sensitive molecules -- 5.4.2. Signaling pathways -- 5.5. Conclusion and perspectives -- Acknowledgments -- References -- Chapter 6: Mechanobiology of osteoclast -- 6.1. Introduction -- 6.2. Osteoclast characteristics -- 6.3. Mechanical stimuli of osteoclast -- 6.3.1. FSS in osteoclast mechanobiology -- 6.3.2. Vibration in osteoclast mechanobiology -- 6.3.3. Mechanical Stretch in osteoclast mechanobiology -- 6.3.4. Compressive force in osteoclast mechanobiology -- 6.3.5. Mechanical unloading microgravity in osteoclast mechanobiology -- 6.4. Osteoclast mechanotransduction -- 6.5. Conclusion and perspectives -- Acknowledgments -- References -- Chapter 7: Mechanobiology of osteocytes -- 7.1. Introduction -- 7.2. Osteocytes
- 7.2.1. Osteocyte characteristics -- 7.2.2. Osteocyte function -- 7.3. Mechanical stimulation of osteocytes -- 7.3.1. Lacunar-canalicular system in osteocyte mechanobiology -- 7.3.2. In vivo stimulation of osteocyte -- 7.4. Mechanisms of osteocyte mechanotransduction -- 7.4.1. Mechanosensing complexes -- 7.4.2. Temporal responses of osteocyte mechanotransduction -- 7.4.3. Signaling pathways in osteocyte mechanotransduction -- 7.4.4. Altered osteocyte mechanotransduction in various diseases -- 7.5. Conclusions and future studies -- Acknowledgments -- References -- Chapter 8: Mechanobiological crosstalk among bone cells and between bone and other organs -- 8.1. Introduction -- 8.2. Subcellular structural basis for mechanosensing and cell communication in bone -- 8.2.1. Ion channels -- 8.2.2. Integrins -- 8.2.3. Cytoskeleton -- 8.2.4. Focal adhesions -- 8.2.5. Primary cilium -- 8.2.6. G protein-coupled receptors -- 8.2.7. Osteocytes and the lacunar-canalicular network -- 8.2.8. Other structures for mechanosensing -- 8.3. Mechanotransduction between adjacent osteocytes: Immobilized, but active mechanosensitive orchestrator -- 8.3.1. Generation of primary biochemical-coupling signals by osteocytes -- 8.3.2. Intercellular transmission of biochemical-coupling signals to adjacent osteocytes -- 8.4. Mechanotransduction between osteoblasts and osteoclasts -- 8.5. Mechanotransduction among osteocytes, osteoblasts, and osteoclasts -- 8.5.1. Crosstalk between osteocytes and osteoblasts -- 8.5.2. Crosstalk between osteocytes and osteoclasts -- 8.5.3. Crosstalk among osteocytes, osteoblasts, and osteoclasts -- 8.6. Mechanotransduction between bone and other organs -- 8.6.1. Osteocyte signaling to kidneys in regulation of phosphate homeostasis -- 8.6.2. Osteocyte-muscle crosstalk -- 8.6.3. Osteocyte-cancer crosstalk -- 8.7. Conclusion and perspectives
- Acknowledgment -- References -- Chapter 9: Mechanobiology of the articular chondrocyte -- 9.1. Introduction -- 9.2. The biomechanical microenvironment of the chondrocyte -- 9.2.1. The mechanical cues in the pericellular matrix -- 9.2.1.1. Matrix stiffness -- 9.2.1.2. Matrix viscoelasticity -- 9.2.1.3. Matrix topography -- 9.2.2. Recapitulation of the mechanical microenvironment -- 9.2.2.1. Engineering strategies -- 9.2.3. The implication of mechanical microenvironment in tissue engineering -- 9.3. Biomechanical characterization of a single chondrocyte -- 9.3.1. Mechanical behaviors of single cells -- 9.3.2. Measurements of single cell mechanics -- 9.3.2.1. Atomic force microscopy -- 9.3.2.2. Micropipette aspiration technique -- 9.3.3. The mechanical behavior of the chondrocyte -- 9.3.3.1. The viscoelastic properties of normal and osteoarthritic chondrocytes -- 9.3.3.2. Matrix stiffness regulates the biomechanical properties of chondrocytes -- 9.3.3.3. Geometry regulates the mechanical properties of chondrocytes -- 9.3.3.4. Hypo-osmotic loading regulates the mechanical behavior of chondrocytes -- 9.4. Mechanosensitive channels are involved in mechanotransduction -- 9.4.1. TRPV4/PIEZOs in chondrocytes -- 9.4.1.1. Activation mechanisms for TRPV4/PIEZO channels -- 9.4.2. TRPV4/PIEZOs mediate mechanical strain -- 9.4.2.1. TRPV4/PIEZOs are involved in osteoarthritic pathogenesis -- 9.4.3. TRPV4/PIEZO mediate chondrocyte sensing matrix physical properties -- 9.4.3.1. Chondrocytes sense substrate stiffness -- 9.4.3.2. Chondrocytes sense matrix geometry -- 9.5. Conclusion and perspectives -- Acknowledgments -- References -- Part III: Bone biomechanics and bone diseases -- Chapter 10: Bone cell mechanobiology and bone disease -- 10.1. Introduction -- 10.2. Bone cell mechanobiology and osteoporosis
- 10.2.1. Bone marrow mesenchymal stem cell mechanobiology and osteoporosis
Subjects
- Bone cells.
- Bones -- Diseases.
- Bones -- Mechanical properties.
- Biomechanical Phenomena
Medical Subject Heading
- Biophysical Phenomena
Medical Subject Heading
- Bone and Bones
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- Bone Diseases
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