1. How To Use This Book -- 2. Clinical Question and Study Design -- 3. Searching the Medical Literature -- 4. Therapy: Assessing the Value of Clinical Interventions -- 5. Non-inferiority Study Designs -- 6. Harm and Causation: Assessing the Value of Studies of Harm -- 7. Diagnostic Testing: Assessing the Value of Studies of Diagnostic Tests -- 8. Screening -- 9. Prognosis -- 10. Systematic Reviews and Meta-Analysis -- 11. Shared Decision Making