Website Search
Find information on spaces, staff, and services.
Catalog Search
Books
Autophagy and metabolism : potential target for cancer therapy
- Available as
- Online
- Summary
-
Autophagy and Metabolism: Potential Target for Cancer Therapy presents updates on autophagy in cancer metabolism and how it can be used to develop new, more efficient treatments. Written by experts...
Autophagy and Metabolism: Potential Target for Cancer Therapy presents updates on autophagy in cancer metabolism and how it can be used to develop new, more efficient treatments. Written by experts in the field, the book presents recent research and explains how to translate it to the clinical setting. Sections discuss tumor cell metabolism and autophagy as therapeutic targets, autophagy regulation in cancer, signaling pathways in metabolic dysregulation in solid tumors, metabolic stress and cell death pathways, and the role of the tumor microenvironment. In addition, topics cover combined targeting autophagy, metabolism for cancer therapy, and the autophagy effect on immune cell metabolism.
Details
- Creator
- edited by Dhruv Kumar and Shailendra Asthana
- Format
- Books
- Language
- English
- Contributors
- Publication
-
- London, England ; San Diego, California : Elsevier, [2022]
- ©2022
- Physical Details
-
- 1 online resource (364 pages)
- ISBNs
- 9780323999458, 0323998798, 9780323998796, 032399945X
- OCLC
- on1340032534
- Includes bibliographical references and index.
- Front Cover -- Autophagy and Metabolism -- Copyright Page -- Contents -- List of contributors -- Preface -- 1 Metabolic dysregulation in cancer progression -- 1.1 Introduction -- 1.1.1 Hallmarks of dysregulated cancer metabolism -- 1.2 Impact of dysregulated metabolism on cancer progression -- 1.2.1 Dysregulated amino acid metabolism and effect on cancer progression -- 1.2.1.1 Arginine and tryptophan metabolism -- 1.2.1.2 Serine and glycine metabolism -- 1.2.1.3 Glutamine metabolism -- 1.2.1.4 Branched-chain amino acid metabolism -- 1.2.1.5 Role of long noncoding RNAs in regulating cancer amino acid metabolism -- 1.2.2 Dysregulated lipid metabolism and effect on cancer progression -- 1.2.3 Dysregulation of RNA metabolism: N6-methyladenosine (m6A) modification -- 1.2.4 Dysregulated mitochondrial metabolism and Warburg effect -- 1.3 Metabolic reprogramming for anchorage-independent growth, and to form metastatic tumors -- 1.4 Targeting dysregulated cancer metabolism: a therapeutic perspective -- 1.4.1 Antimetabolite chemotherapy, inhibitors of nucleotide synthesis, and antifolates -- 1.4.2 Repurposing common metabolic agents-vit C, vit D, aspirin, metformin -- 1.5 Conclusion -- References -- 2 Molecular dynamics of autophagy in cancer metabolism -- 2.1 Introduction -- 2.2 Autophagy -- 2.2.1 Microautophagy -- 2.2.2 Chaperone-mediated autophagy -- 2.2.3 Macroautophagy -- 2.2.4 Metabolic reprogramming -- 2.2.5 Crosstalk between metabolic reprogramming and autophagy in carcinogenesis -- 2.3 Molecular mechanism of macroautophagy -- 2.3.1 Initiation -- 2.3.2 Nucleation -- 2.3.3 Maturation -- 2.3.4 Fusion and degradation -- 2.4 Autophagy regulation by metabolic stimuli -- 2.4.1 Nutrient starvation -- 2.4.2 Glucose -- 2.4.3 Amino acids -- 2.4.4 Lipids and free fatty acid -- 2.5 Molecular mechanism of autophagy regulation
- 2.5.1 Target of rapamycin TOR/mammalian target of rapamycin -- 2.5.2 Phosphatidylinositol 3-kinase-I/ protein kinase B (PKB) -- 2.5.3 Beclin-1/phosphatidylinositol 3-kinase-III -- 2.5.4 Guanosine triphosphateases -- 2.5.5 Calcium -- 2.5.6 p53 and autophagy -- 2.5.7 Survivin and autophagy -- 2.6 Cancer regulation via autophagy -- 2.6.1 Tumor suppressor mechanism of autophagy -- 2.6.1.1 Oxidative stress and genetic instability -- 2.6.1.2 Necrosis and inflammation -- 2.6.2 Oncogenic mechanism of autophagy -- 2.6.2.1 Ras-dependent tumor progression -- 2.6.2.2 Ras-independent tumor progression -- 2.7 Therapeutics targeting autophagy -- 2.7.1 In vitro studies -- 2.7.2 Clinical trials -- 2.8 Conclusion -- References -- 3 Tumor cell metabolism and autophagy as therapeutic targets -- 3.1 Introduction -- 3.2 Cancer metabolism in the tumor microenvironment -- 3.2.1 Cancer-associated fibroblasts -- 3.2.2 Endothelial cells -- 3.3 Metabolism of macrophages in tumor microenvironment -- 3.3.1 Tumor-associated macrophages metabolism in the proliferation of tumor cells -- 3.3.2 Effect of tumor-associated macrophages metabolism on the immune system -- 3.3.3 Tumor-associated macrophages and tumor cells -- 3.4 Altered metabolic enzymes -- 3.4.1 Glucose metabolism -- 3.4.2 Serine synthetic pathway -- 3.4.3 Glutamine and fatty acid metabolism -- 3.5 Role of autophagy in cancer -- 3.5.1 Cancer metabolism and autophagy -- 3.5.2 Autophagy as a therapeutic target -- References -- 4 Autophagy regulation in cancer: current knowledge on action and therapy -- 4.1 Introduction -- 4.2 Regulation of autophagy -- 4.2.1 ATG12-ATG5-ATG16L complex -- 4.2.2 PABPC1-FAM134B-ER phagy pathway -- 4.2.3 Forkhead box K2 -- 4.2.4 FKBP4/NR3C1/TMEM173 signaling pathway -- 4.2.5 Major histocompatibility complex class I -- 4.2.6 Sestrin 2 participates in autophagy induction
- 4.2.7 Signal transducer and activator of transcription 3 -- 4.3 Anticancer autophagy inhibitors -- 4.3.1 Anticancer autophagy inhibitors -- 4.4 Conclusion -- References -- 5 Signaling pathways in metabolic dysregulation in solid tumors -- 5.1 Introduction -- 5.2 Metabolic pathways associated with tumor progression -- 5.2.1 Carbohydrate metabolism in tumor -- 5.2.2 Lipid metabolism in tumor -- 5.2.3 Amino acid metabolism -- 5.2.4 Mitochondrial metabolism in tumor cells -- 5.3 Signaling pathways associated with solid tumors -- 5.3.1 PI3K-Akt-mTOR pathway -- 5.3.2 Wnt/β-catenin signaling -- 5.3.3 Hedgehog signaling -- 5.3.4 Mitogen-activated protein kinase pathway -- 5.3.5 Notch signaling -- 5.4 Tissue-specific tumorigenesis and its metabolic dysregulation -- 5.4.1 Metabolic dysregulation in clear-cell renal cell cancer -- 5.4.1.1 Glycolysis metabolism -- 5.4.1.2 Fatty acid metabolism -- 5.4.2 Metabolic dysregulation in prostate cancer -- 5.4.2.1 Glucose metabolism -- 5.4.2.2 Fatty acid metabolism -- 5.4.2.3 Amino acid metabolism -- 5.4.2.4 Signaling pathways of metabolic reprogramming in prostate tumor -- 5.4.3 Metabolic reprogramming in brain tumor (glioblastoma) -- 5.4.3.1 Aerobic glycolysis in the brain -- 5.4.3.2 Mitochondria in glioma -- 5.4.3.3 Fatty acid metabolism -- 5.4.3.4 Signaling pathways of metabolic reprogramming in brain tumor -- 5.4.4 Metabolic dysregulation in melanoma tumor -- 5.4.4.1 Glycolysis metabolism -- 5.4.4.2 Fatty acid metabolism -- 5.4.4.3 Signaling pathways of metabolic reprogramming in melanoma cancer -- 5.5 Therapeutic approaches targeting oncogenic signaling in solid tumor -- 5.5.1 Gene therapy -- 5.5.1.1 Viral vector -- 5.5.1.2 Nonviral -- 5.5.2 Targeting signaling pathways as a therapeutic lead -- 5.6 Conclusions and future directions -- References -- 6 Autophagy in arsenic exposed population and cancer patients
- 6.1 Global arsenic scenario -- 6.2 Indian arsenic scenario -- 6.3 Bihar arsenic scenario -- 6.4 Cancer scenario -- 6.5 Disease cause -- 6.6 Autophagy in arsenic exposed population -- 6.7 Autophagy in cancer patients -- 6.8 Conclusion -- References -- 7 Autophagy in cancer-associated fibroblasts: biology and targeting -- 7.1 Introduction -- 7.2 Cancer-associated fibroblast -- 7.2.1 Cancer-associated fibroblast identification -- 7.2.2 Source and heterogeneity in cancer-associated fibroblasts -- 7.2.3 Role of cancer-associated fibroblasts in cancer progression -- 7.3 Autophagy in cancer-associated fibroblast in cancer progression -- 7.3.1 Amino acid -- 7.3.2 Growth factor, cytokine, and chemokines -- 7.3.3 Autophagy maintains the cancer-associated fibroblast phenotype, keeping them from dedifferentiating to normal fibroblast -- 7.4 Targeting cancer-associated fibroblast autophagy for oncologic treatment -- 7.4.1 Targeting autophagy in current clinical trials for cancer treatment -- 7.4.2 Clinical trials targeting cancer-associated fibroblasts -- Funding -- References -- 8 Autophagy and metabolic regulation in cancer and its application in drug discovery -- 8.1 Introduction -- 8.2 Molecular mechanism of autophagy -- 8.3 Initiation of phagophore formation -- 8.4 Elongation -- 8.5 Maturation and fusion -- 8.6 Major autophagy-regulating targets -- 8.6.1 Autophagy and diseases -- 8.7 Autophagy and cancers -- 8.8 Mechanism of tumor suppression -- 8.9 Mechanism of tumor promotion -- 8.10 Therapeutic targets of autophagy in cancers -- 8.11 Conclusions and prospects -- References -- 9 Mitophagy in cancer and cancer stem cells: a role in metabolic reprogramming -- 9.1 Introduction -- 9.2 Mitochondrial function and dynamics -- 9.3 Introduction to mitophagy -- 9.4 The mechanism of mitophagy -- 9.4.1 PINK1-Parkin-mediated mitophagy
- 9.4.2 Alternative mitophagy mechanisms -- 9.5 Mitophagy and diseases -- 9.6 Mitophagy and cancer -- 9.6.1 The PINK1-PARKIN pathway in cancer -- 9.6.2 Role of mitochondrial fission and fusion in cancer -- 9.7 Mitophagy and cancer stem cells -- 9.8 Mitophagy in cancer stem cell drug-resistance -- 9.9 Concluding remarks -- References -- 10 Combined targeting autophagy and metabolism for cancer therapy -- 10.1 Introduction -- 10.2 Autophagy: an introduction -- 10.3 Molecular mechanism of autophagy -- 10.4 Autophagy and cancer -- 10.5 Role of autophagy inducers in cancer therapy -- 10.6 Role of autophagy inhibitors in cancer therapy -- 10.7 Conclusion -- References -- 11 Designing metabolic target-specific inhibitors for cancer therapy -- 11.1 Introduction -- 11.2 Role of metabolic target-specific inhibitors for cancer therapeutics -- 11.2.1 Glycolytic pathway targeted by novel anticancer drugs and phytochemicals -- 11.2.2 Effect of inhibitors on fatty acid metabolism -- 11.2.3 The therapeutic approach of phytochemicals toward the tricarboxylic acid cycle -- 11.2.4 De novo nucleotide biosynthesis and folate cycle inhibitors -- 11.2.5 Purine nucleotide synthesis -- 11.2.6 Pyrimidine nucleotide synthesis mechanism -- 11.2.7 Serine biosynthesis mechanism and Folate cycle -- 11.2.8 Tumor cells can tune the signal transduction pathways to allow synthesis of nucleotides -- 11.2.9 Advances in targeting the folate receptor -- 11.2.10 Metabolic inhibitors targeting urea cycle-methionine cycle -- 11.3 Conclusion -- Conflict of Interest -- Author contributions -- Abbreviations -- References -- 12 Interplay between gut microbiota and autophagy in human health -- 12.1 Autophagy -- 12.1.1 An overview of autophagy -- 12.1.2 Role of autophagy in gastrointestinal homeostasis -- 12.2 Gut microbiota -- 12.2.1 Technologies used to detect the gut microbiota
- 12.2.2 Factors affecting the gut microbiota composition
Subjects
- Cancer -- Treatment.
- Cell death.
- Neoplasms -- metabolism
Medical Subject Heading
- Neoplasms -- drug therapy
Medical Subject Heading
- Autophagy
Medical Subject Heading
- Antineoplastic Agents
Medical Subject Heading
- Drug Discovery
Medical Subject Heading