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Nitrosoureas : current status and new developments
- Available as
- Online
- Summary
-
Nitrosoureas: Current Status and New Developments covers the preclinical and clinical status of nitrosoureas. The book presents preclinical studies on the development of the nitrosoureas; combinati...
Nitrosoureas: Current Status and New Developments covers the preclinical and clinical status of nitrosoureas. The book presents preclinical studies on the development of the nitrosoureas; combination chemotherapy with nitrosoureas plus other anticancer drugs against animal tumors; EORTC studies with novel nitrosoureas; and chemical decomposition of chloroethylnitrosoureas. The text also includes preclinical studies on the metabolism of nitrosoureas; DNA crosslinking and the origin of sensitivity to chloroethylnitrosoureas; modification of DNA and RNA bases; and carbamoylating activity of nitr.
Details
- Creator
- edited by Archie W. Prestayko [and others]
- Format
- Books
- Language
- English
- Contributors
- Publication
-
- New York : Academic Press, 1981
- Physical Details
-
- 1 online resource (xix, 416 pages) : illustrations
- data file
- ISBNs
- 9781483219448, 1483219445, 0125650604, 9780125650601
- OCLC
- ocn624409264
- Includes bibliographical references.
- Front Cover; Nitrosoureas: Current Status and New Developments; Copyright Page; Table of Contents; Contributors; Preface; Section I: PRECLINICAL STUDIES; Chapter 1. The Development of the Nitrosoureas: A Study in Congener Synthesis; I. N-Nitroso Function; II. Chloroethyl Moiety; III. Antitumor Activity in Animal Tumors; IV. Conclusion; References; Chapter 2. Combination Chemotherapy with Nitrosoureas plus Other Anticancer Drugs against Animal Tumors; I. Introduction; II. Biologic Activity of Nitrosoureas in Combination with Other Anticancer Drugs; III. Discussion; IV. Summary; References
- Chapter 3. EORTC Studies with Novel NitrosoureasI. Introduction; II. The Chemotherapeutic Activity of HECNU and Other NU Derivatives; III. Selecting among NU Analogs; IV. Conclusion; ACKNOWLEDGMENT; References; Chapter 4. Chemical Decomposition of Chloroethylnitrosoureas; I. Introduction; II. Decomposition of Nitrosoureas; III. Decomposition of Other ""Nitroso"" Compounds; IV. Conclusion; References; Chapter 5. Metabolism of Nitrosoureas; I. Introduction; II. Materials and Methods; III. Results; IV. Discussion; V. Conclusions; VI. References
- Chapter 6. DNA Crosslinking and the Origin of Sensitivity to ChloroethylnitrosoureasI. Introduction; II. Materials and Methods; III. Results; IV. Discussion; References; Chapter 7. Modification of DNA and RNA Bases; I. Introduction; II. Materials and Methods; III. Results; IV. Discussion; References; Chapter 8. Carbamoylating Activity of Nitrosoureas; I. Introduction; II. Materials and Methods; III. Results; IV. Discussion; ACKNOWLEDGMENT; References; Chapter 9. Chromatin and Associated Nuclear Components as Potential Drug Targets; I. Introduction; II. Results
- III. Conclusion and PerspectivesReferences; Chapter 10. ADP-Ribosylation and DNA Repair as Induced by Nitrosoureas; I. Introduction; II. Results and Discussion; III. Conclusion; ACKNOWLEDGMENT; References; SECTION II: CLINICAL STUDIES; Chapter 11. Subacute and Chronic Toxicities Associated with Nitrosourea Therapy; I. Introduction; II. Pulmonary Toxicity; III. Renal Toxicity; IV. Other Adverse Effects; V. Conclusions; ACKNOWLEDGMENT; References; Chapter 12. The Toxicity of High-Dose BCNU with Autologous Marrow Support; I. Introduction; II. Materials and Methods; III. Results; IV. Discussion
- V. ConclusionReferences; Chapter 13. Clinical Pharmacology of the Nitrosoureas; I. Introduction; II. General Methods; III. Pharmacokinetic Data; IV. Discussion; V. Conclusion; References; Chapter 14. Nitrosoureas in the Therapy of Hodgkin's Disease; I. Introduction; II. Materials and Methods; III. Results; IV. Discussion; References; Chapter 15. Hodgkin's Disease and Malignant Lymphomas; I. Introduction; II. Materials and Methods; III. Results and Discussion; IV. Conclusion; References; Chapter 16. CCNU in Combination Chemotherapy Programs for Small-Cell Lung Cancer
Subjects
- Nitrosoureas -- Therapeutic use -- Congresses.
- Cancer -- Chemotherapy -- Congresses.
- Nitrosoureas -- Testing -- Congresses.
- Nitrosoureas -- Metabolism -- Congresses.
- Drug Evaluation, Preclinical.
Medical Subject Heading
- Drug Evaluation.
Medical Subject Heading
- Neoplasms -- drug therapy.
Medical Subject Heading
- Nitrosourea Compounds -- pharmacology.
Medical Subject Heading
- Nitrosourea Compounds -- therapeutic use.
Medical Subject Heading