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Books
New therapies to prevent or cure auditory disorders
- Available as
- Online
Details
- Creator
- Sylvie Pucheu, Kelly E. Radziwon, Richard Salvi, editors
- Format
- Books
- Language
- English
- Contributors
- Publication
-
- Cham : Springer, 2020
- Physical Details
-
- 1 online resource
- data file
- ISBNs
- 3030404129, 9783030404154, 9783030404130, 9783030404123, 9783030404147, 3030404137
- OCLC
- on1148219726
- Intro -- Introduction -- Contents -- Lifestyle Intervention to Prevent Age-Related Hearing Loss: Calorie Restriction -- 1 Introduction -- 2 Effects of Age on Auditory Function -- 3 Effects of Calorie Restriction on Aging -- 3.1 Types of Calorie Restriction Regimens -- 3.2 Effects of Calorie Restriction on Hearing Loss in Laboratory Animals -- 4 Mechanisms Underlying the Beneficial Effects of CR on AHL -- 4.1 Oxidative Stress -- 4.2 Apoptosis -- 4.3 mtDNA Mutations -- 5 Conclusion -- References -- Noise-Induced Hearing Loss and Drug Therapy: Basic and Translational Science -- 1 Introduction
- 2 Cochlear Pathology -- 2.1 Oxidative Stress -- 2.2 Cochlear Blood Flow Changes -- 2.3 Apoptotic Cell Death -- 2.4 Mechanical Damage and Stereocilia Injury -- 3 Noise-Induced Deafferentation -- 3.1 Consequences of Synaptopathy -- 4 Auditory Threshold Shift as a Measure of Noise-Induced Hearing Loss -- 4.1 Extended High-Frequency Audiometry -- 5 Effects of Noise on Suprathreshold Measures of Hearing -- 5.1 Speech-in-Noise Testing -- 6 Pharmaceutical Otoprotection from Noise-Induced Hearing Loss -- 6.1 Antioxidants -- 6.2 Steroid Therapy -- 6.3 S-Ketamine and Glutamate Excitotoxicity
- 6.4 Cell Death and Stress Inhibitors -- 7 Summary -- References -- Review of Ototoxic Drugs and Treatment Strategies for Reducing Hearing Loss -- 1 Significance and Background -- 2 Cisplatin Ototoxicity -- 2.1 Entry of Cisplatin into the Cochlea -- 2.2 Mechanisms Underlying Cisplatin Ototoxicity -- Increased Oxidative Stress -- Promoting Cellular Apoptosis -- Covalent Modification of DNA -- 2.3 Pharmacogenomics of Cisplatin Ototoxicity -- 2.4 Approaches to Treating Cisplatin Ototoxicity -- Relieving Oxidative Stress -- Targeting Cochlear Inflammation
- Drugs Targeting G Protein-Coupled Receptors for Treating Cisplatin Ototoxicity -- 2.5 Ongoing Clinical Trials for Cisplatin Ototoxicity -- 3 Cyclodextrin-Induced Hearing Loss -- 4 Aminoglycosides -- 4.1 Overview -- 4.2 Studies Showing Hearing Loss -- 4.3 Uptake of Aminoglycosides into the Cochlea -- 4.4 Aminoglycoside Genetic Susceptibility -- 4.5 Preventative Strategies for Ototoxicity -- Antioxidants -- Inhibition of Apoptosis -- Mechanoelectrical Transducer Channel Blockers -- 5 Summary -- References -- Approaches to Regenerate Hair Cell and Spiral Ganglion Neuron in the Inner Ear
- 1 Introduction -- 1.1 Global Estimates and Impact of Hearing Impairment -- 1.2 Categories of Hearing Loss -- 1.3 Native HCs Regeneration Capacity in Mammals and Non-mammals -- 2 Approaches to Regenerate HCs and SGNs -- 2.1 Gene Therapy -- Cochlear Gene Therapy Vehicles -- 2.2 Key Signaling Pathway Genes for HC Regeneration -- 2.3 Atoh1-Based Gene Therapy -- 2.4 Inactivation of Cell Cycle Inhibitors Based Gene Therapy -- 2.5 Gene Therapy for SGN Regeneration -- 3 Stem Cell Therapy -- 4 Conclusion -- References