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Systemic lupus erythematosus : basic, applied and clinical aspects
- Available as
- Online
- Summary
-
"Distills current understanding of the cellular, molecular, genetic and environmental factors that instigate and drive the disease Includes comprehensive coverage of clinical features, including fa...
"Distills current understanding of the cellular, molecular, genetic and environmental factors that instigate and drive the disease Includes comprehensive coverage of clinical features, including fatigue, organ system manifestations, overlap syndromes, infections, and more Conveys the very latest understanding of mechanisms of tissue damage, including immune complexes, antibodies, and other mechanisms that lead to organ damage Discusses the latest treatment options on disease modifying or disease controlling agents Provides 'one stop' coverage of all the latest scientific and clinical developments in SLE: new concepts in epidemiology, disease activity measures and outcomes; new concepts in immunoregulation, genetic and pathogenic mechanisms; new understanding and novel presentation of the processes of tissue/organ damage; comprehensive coverage of clinical features; and the very latest concepts in treatment"--
Details
- Creator
- edited by George C. Tsokos, Professor of Medicine, Harvard Medical School, and Chief, Rheumatology Division, Beth Israel Deaoness Medical Center, Boston, MA, United States
- Format
- Books
- Language
- English
- Contributors
- Publication
-
- Second edition
- London : Academic press, an imprint of Elsevier, [2020]
- ©2020
- Physical Details
-
- 1 online resource (xxix, 652 pages) : color illustrations
- ISBNs
- 012814551X, 0128145528, 9780128145524, 9780128145517
- OCLC
- on1150240738
- Introduction to the second edition -- History of systemic lupus erythematosus with an emphasis on certain recent major issues -- The patient -- A plea of a young patient to the lupus experts -- Epidemiology -- Measuring disease activity -- Disease development and outcome -- Socioeconomic aspects of SLE -- Biomarkers in systemic lupus erythematosus -- Overview of the pathogenesis of systemic lupus erythematosus -- System lupus erythematosus and the environment -- Genes and genetics in human SLE -- Monogenic lupus -- Hormones -- Clinical aspects of the complement system in systemic lupus erythematosus -- T cells -- B cells in SLE -- Neutrophils in systemic lupus erythematosus -- The role of dendritic cells in systemic lupus erythematosus -- Cytokines -- RNA/DNA sensing in SLE--Toll-like receptors and beyond -- The role of interferons in systemic lupus erythematosus -- Fcγ receptors in autoimmunity and end-organ damage -- Apoptosis, autophagy, and necrosis -- Infections in early systemic lupus erythematosus pathogenesis -- Microbiota influences on systemic lupus erythematosus and Sjögren's syndrome -- Origin of autoantibodies -- Anti-DNA antibodies -- Antihistone and antispliceosome antibodies -- Immune complexes in systemic lupus erythematosus -- MicroRNA in systemic lupus erythematosus -- Metabolic control of lupus pathogenesis: central role for activation of the mechanistic target of rapamycin -- Epigenetics -- What do mouse models teach us about human SLE? -- Genes and genetics of murine systemic lupus erythematosus -- Mechanisms of renal damage in systemic lupus erythematosus -- Mechanisms of vascular damage in systemic lupus erythematosus -- The mechanism of skin damage -- Pathogenesis of tissue injury in the brain in patients with systemic lupus erythematosus -- Constitutional symptoms and fatigue in systemic lupus erythematosus -- The musculoskeletal system in SLE -- Cutaneous lupus erythematosus -- The clinical evaluation of kidney disease in systemic lupus erythematosus -- The pathology of lupus nephritis -- Cardiovascular disease in systemic lupus erythematosus: an update -- The lung in systemic lupus erythematosus -- Gastrointestinal, hepatic, and pancreatic disorders in systemic lupus erythematosus -- Systemic lupus erythematosus and infections -- Malignancies in systemic lupus erythematosus -- The nervous system in systemic lupus erythematosus -- Overlap syndromes -- Systemic lupus erythematosus and the eye -- Fertility and pregnancy in systemic lupus erythematosus -- Neonatal lupus: Clinical spectrum, biomarkers, pathogenesis, and approach to treatment -- Incomplete lupus syndromes -- Lupus in children -- Drug-induced lupus -- Vasculitis in lupus -- Pathogenesis of antiphospholipid syndrome -- Antibodies and diagnostic tests in antiphosholipid syndrome -- Clinical manifestations -- Nonsteroidal antiinflammatory drugs in systemic lupus erythematosus -- Value of antimalarial drugs in the treatment of lupus -- Systemic glucocorticoids -- Cytotoxic drug treatment -- Treatment of antiphospholipid syndrome -- New treatments of systemic lupus erythematosus -- Repositioning drugs for systemic lupus erythematosus
Subjects
- Systemic lupus erythematosus.
- Lupus Erythematosus, Systemic -- diagnosis.
Medical Subject Heading
- Lupus Erythematosus, Systemic -- physiopathology.
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- Lupus Erythematosus, Systemic -- therapy.
Medical Subject Heading
- Lupus Erythematosus, Systemic.
Medical Subject Heading
- Biomarkers.
Medical Subject Heading
- Comorbidity.
Medical Subject Heading