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Objective Biometric Methods for the Diagnosis and Treatment of Nervous System Disorders
- Author / Creator
- Available as
- Online
- Summary
-
Objective biometric methods for the diagnosis and treatment of nervous system disorders provides a new unifying methodological framework, introducing new objective biometrics to characterize patter...
Objective biometric methods for the diagnosis and treatment of nervous system disorders provides a new unifying methodological framework, introducing new objective biometrics to characterize patterns of sensory motor control underlying symptoms. Its goal is to radically transform the ways in which disorders of the nervous system are currently diagnosed, tracked, researched and treated. This book introduces new ways to bring the laboratory to the clinical setting, to schools and to settings of occupational and physical therapy. Ready-to-use graphic user interfaces are introduced to provide outcome measures from wearable sensors that automatically assess in near real time the effectiveness of interventions. Lastly, examples of how the new framework has been effectively utilized in the context of clinical trials are provided.--
Details
- Creator
- Elizabeth B. Torres
- Format
- Books
- Language
- English
- Publication
-
- London, England : Elsevier, 2018
- Physical Details
-
- 1 online resource (580 pages)
- ISBNs
- 9780128041185, 0128041188, 9780128040829, 0128040823
- OCLC
- on1041152700
- Includes bibliographical references and index.
- Front Cover -- Objective Biometric Methods for the Diagnosis and Treatment of Nervous System Disorders -- Copyright Page -- Contents -- Preface -- 1 The Closed Feedback Loops Between the Peripheral and the Central Nervous Systems, the Principle of Reafference and Its Co... -- Part I: Searching for Volition While in a Comma State -- Serendipitous Encounters -- From Spontaneous Random Noise to Well-Structured Signals -- The Micro-Movements Perspective -- Distinguishing Deliberateness From Spontaneity in Kinematics Signals -- From Volition to the Path of Rehabilitation -- Revisiting the Principle of Reafference -- Part II: Physical Growth and Neurodevelopment in Neonates -- Some Detective Work -- The USC Baby Data -- The Pre-Labeled Data Showed Differences in the Rates of Anatomical Increment Across the Babies -- Data-Driven Approach -- Scale-Free Relation Between Two Nonlinear and Non-Gaussian Processes of a Complex System -- Conclusions -- Appendix-First-Order Stochastic Rule -- References -- 2 Critical Ingredients for Proper Social Interactions: Rethinking the Mirror Neuron System Theory -- Part I -- The Human Mirror Neuron Systems -- Mirror Neuron Systems Without Reafferent Codes -- Rethinking Simulation Theory -- Dissecting Simulation Theory -- How Do I Know It's Me Moving My Own Body With Agency? -- A Different Paradigm to Study Decision-Making -- Blindly Predicting the Task From the Performance Variability -- Some Additional Thoughts -- Part II: A Small Pedagogical Parenthesis About Taking Motor Control to the Classroom in a Do-It-Yourself Setting -- Physical Movement Kinematics as a Window Into Mental Decisions -- Where to Go With This? -- Self-Supervision: Distinguishing My Self-Generated Kinesthetic Noise From Extraneous Noise -- Self-Discovering Cause and Effect: Autonomy From the Bottom-Up
- The Bridge Between Mental Intent and Physical Volition -- Habilitation and Enhancement of Volition to Evoke Vocalization -- References -- 3 The Case of Autism Spectrum Disorders: When One Cannot Properly Feel the Body and Its Motions From the Start of Life -- Part I: How do you Measure Autism? -- Measuring ASD Objectively, That is -- One Plain Random Process in Nature vs Many Running in Tandem Within Interconnected Systems Poised to Develop Intelligence -- An AHA! Moment -- Empirically Driven Ideas Inspired on Biorhythms' Statistics -- Back to the Drawing Board? -- Anchors of Known Etiology and Longitudinal Dynamic Diagnoses -- Mind the Gap: Behavior is Much More Than Mouse Clicks -- Science Meets Technology Transfer and Commercialization -- Parameterizing Changes in the Nervous Systems in Near Real Time -- Part II: Physiological Signals Underlying Cognitive Decisions -- Designing Appropriate Cognitive-Motor Tasks -- Motor Research With Children is More Challenging so it Requires New Methods -- Increase in Cognitive Loads Induces Adaptive Motor Learning -- Adaptive Motor Learning Helps Decision Accuracy -- Sensing Through Movement: When not all Noise is Created Equal -- From the Brain to the Heart -- The Autistic Somatic-Motor Phenotype -- Forty Subjects are not Enough -- When Open Access Came to the Rescue -- References -- 4 The Case of Schizophrenia: Is that My Arm Moving on Purpose or Spontaneously Passing by? -- Part I Predictive Reach: From Brownies to a PDE -- Finding a Problem Worthy of a PhD Thesis in Cognitive Science -- Rethinking Some Questions to Ask in Neural Motor Control -- Two Vantage Points: The External Observer vs. the Internal Nervous System -- Justifying a Geometric Approach to Movement Modeling -- The Geometrization of the DoF Problem to Move along the Shortest Paths in Space and Time -- Generating Unique Geometric Solutions
- Locally Linear Isometric Embedding of X into Q -- DoF Decomposition, Recruitment, and Release according to Task Demands -- Empirical Evidence for Speed Invariance -- Invariants of the Geodesic-Generating PDE -- My Time at CALTECH: In Search for Evidence within the Neural Code -- Geometric Invariants of Unconstrained Actions -- Part II Switching Research Paths for Clinical Applications -- The Experimental Paradigm -- Parsing DoF Reveals Excess Deliberateness in Automatic Movement Segments of PD Patients -- Defining Forward Reach Goals -- Defining Goals for Reaching Back to a Sensed Posture -- Schizophrenia Patients: Did I Mean to Do What I Just Did? -- Appendix 1 -- Coordinate Charts and the Inner Product -- Appendix 2 -- The Gauss Map and Its Differential -- Appendix 3 -- Testing Geodesic Property and Obtaining Curvature Measures with the Model -- Appendix 4 -- Switching between Tasks -- Appendix 5 -- Coordinate Transformations and New Distance Metrics -- Appendix 6 Numerical Estimation of Positive Definite Coordinate Transformation Matrix -- References -- 5 Learning to Detect Expertise in Sports Aided by the Gift of Our Students -- Uncertain Times -- Surviving Immigration -- Spotting Genius -- Joe Vero -- Ushma Majmudar -- Neha Tadimeti -- Jillian Nguyen -- Measuring Motor Learning in Sports -- Uri Yarmush -- Designing a Motor Control Experiment using Sports -- Bernstein's DoF Problem in the Boxing Routines -- De-adaptation from New Dynamics can Surprise your Opponent -- Sensing the Future Speed in Different Contexts -- References -- 6 Rethinking Diagnoses and Treatments of Disorders: The Third (Objective) Neutral Observer Assessing the Interactions betwe... -- From Ballet to Personalized Precision Psychiatry -- Some Thoughts on Our Social Mental Spaces -- Nobody Prints! -- But First, Mind the Gap!
- Ballet Partnering: The Dance of Coupled Biorhythms -- Dynamic Diagnostics and Outcome Measures Using Phylogenetically Orderly Taxonomy -- Reciprocally Connected Network -- Additional Tools to Summarize Coupled PNS-CNS Modules as a Measure of Sub-Networks' Togetherness -- Summary Statistics Profile -- Closing the Feedback Loops in Parametric Form -- Toward Dyadic Interactions between Children and Avatars -- The ADOS Dyadic Exchange: Another Form of Social Dance -- Two Wings of the Same Bird -- References -- 7 Different Biometrics for Clinical Trials That Measure Volitional Control -- Part I Opening Pandora's Box -- The Hope Keepers of SMIL -- From Deliberate Autonomy to a Measure of Quality of Life -- From Involuntary Head Motion in fMRI to Faulty Diagnosis of ASD -- Dual Diagnosis and Recommended Treatments in Neurodevelopmental Disorders Under Pre-Imposed Assumptions -- The DSM -- Pandora's Box Let Out Something Awful -- Excess Noise in Autism -- Significance and Potential Consequences of These Results -- The Age-Dependent Shifts in Probability Distribution Functions -- The ADOS -- The 5:1 Females to Males (Statistically Impossible) Ratio of ASD -- Part II Biomarkers for Clinical Trials -- SHANK3 Deletion Syndrome -- Tracking a Clinical Trial Using Gait Biometrics -- The Critical Baseline Measurement -- Visualization Tools -- Longitudinal Tracking of Somatic-Motor Change Across the Group -- Individualized Tracking of Trial Effects -- References -- Appendix -- Autism Diagnostics by Site -- ADI-R -- ADOS -- ADOS_Gotham -- ADOS_G -- ADOS-2 -- 8 Adding Dynamics to the Principle of Reafference: Recursive Stochastic Feedback Closed Control Loops to Evoke Autonomy -- Part I Everything Is Sound -- A Wink and a Blink Contain a Spontaneous Segment-And so Does a Reach, a Walk, and Every Other Complex Bodily Movement
- Let's Play Back the Sounds We Make When We Move -- Exploring Sound Preferences: Entrainment Beneath Awareness -- Objective Outcome Measures of Treatments: Drug Trial Revisited -- Objective Outcome Measures of Treatments: Sensory-Based OT -- Closing Remarks -- References -- Index -- Back Cover