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Apprentices to genius : a tribute to Solomon H. Snyder
- Available as
- Online
Details
- Creator
- edited by Gavril W. Pasternak [and three others]
- Format
- Books
- Language
- English
- Contributors
- Publication
-
- Cambridge, Massachusetts : Academic Press, 2018
- ©2018
- Physical Details
-
- 1 online resource (372 pages) : illustrations (some color)
- ISBNs
- 0128140879, 0128140887, 9780128140888, 9780128140871
- OCLC
- on1020789546
- Includes bibliographical references at the end of each chapters.
- Front Cover -- Apprentices to Genius: A tribute to Solomon H. Snyder -- Copyright -- Contents -- Contributors -- Preface -- Appendix -- Foreword -- Chapter One: Multiple Pathways Mediate MicroRNA Degradation: Focus on the Translin/Trax RNase Complex -- 1. Introduction -- 2. Canonical View of MicroRNA Synthesis and MicroRNA-Mediated Silencing -- 3. Focus on MicroRNA Degradation -- 4. Identification of the Translin/Trax Complex -- 5. Does the Translin/Trax Complex Mediate Dendritic Trafficking of mRNAs? -- 6. Surprising Discovery of Translin/Trax RNase Activity -- 7. Translin/Trax Mediates MicroRNA Degradation -- 8. Lin-28 and Translin/Trax Pathways Target Different Features of pre-miRNAs -- 9. Critical Differences Between siRNA and miRNA Silencing Pathways -- 10. Multiple Pathways of MicroRNA Degradation Confer Versatility -- 11. Clues to Regulation of Translin/Trax -- 12. RNase-Independent Functions of Trax -- 13. Conclusion -- Conflict of Interest -- References -- Chapter Two: Receptor Binding Assays and Drug Discovery -- 1. Introduction -- 1.1. The Snyder Approach to the Development of Neurotransmitter Receptor Binding Assays -- 1.2. Applications -- 2. Receptor Binding Assays and Drug Discovery -- 2.1. Compound Screening -- 2.2. Limitations of Ligand Binding Assays in Drug Discovery -- 2.3. Functional, Phenotypic Screening -- 3. Conclusion -- Acknowledgment -- Conflict of Interest -- References -- Chapter Three: The Role of Serine Racemase in the Pathophysiology of Brain Disorders -- 1. Introduction -- 2. Schizophrenia -- 3. Addictions -- 4. Anxiety Disorders -- 5. Brain Damage -- 6. Conclusion -- Conflict of Interest -- Acknowledgments -- References -- Chapter Four: Nitric Oxide Signaling in Neurodegeneration and Cell Death -- 1. Introduction -- 2. Historical Perspective -- 3. Nitric Oxide Mediates Glutamate Excitotoxicity
- 4. nNOS Contributes to Neuronal Toxicity -- 5. Inducible Nitric Oxide Synthase Contributes to Neuronal Toxicity -- 6. Inhibitors of Nitric Oxide Synthase -- 7. Mechanism of Nitric Oxide Neuronal Toxicity -- 8. Conclusion -- Conflict of Interest -- Acknowledgments -- References -- Chapter Five: Carboxypeptidase E and the Identification of Novel Neuropeptides as Potential Therapeutic Targets -- 1. Introduction -- 1.1. Peptides and Peptide Receptors as Pharmacological Targets -- 2. Biosynthesis of Neuropeptides: Discovery of Enkephalin Convertase/Carboxypeptidase E -- 3. CPE and the Discovery of Novel Neuropeptides -- 3.1. Using Mice Lacking CPE to Identify Novel Neuropeptides: Discovery of proSAAS-Derived Peptides -- 3.2. Matching "Orphan" Peptides and Receptors -- 4. Conclusion -- Conflict of Interest Statement -- Acknowledgments -- References -- Chapter Six: Regulation of Mitochondrial, Cellular, and Organismal Functions by TSPO -- 1. Introduction -- 2. TSPO as a Housekeeping Gene -- 2.1. TSPO and Gene Expression -- 2.2. Programmed Cell Death -- 3. TSPO in Evolution -- 4. TSPO and Mitochondrial and Cellular Functions -- 4.1. TSPO-Tetrapyrrole Interaction -- 4.2. Metabolism -- 4.3. Generation of ROS and Oxidative Stress -- 4.4. The Mitochondrial Respiratory Chain -- 4.5. Phosphorylation and Nitrosylation -- 4.6. Steroidogenesis -- 5. TSPO and Developmental Processes -- 5.1. Cell Cycle -- 5.2. TSPO and Cell Proliferation -- 5.3. TSPO and Differentiation -- 5.4. TSPO and Adhesion, Migration, and Angiogenesis -- 5.5. TSPO in Reproductive Processes and Embryonic Development -- 6. Primary Mechanisms Underlying TSPOs Various Functions -- 6.1. TSPO Structure -- 6.2. Cellular Location -- 6.3. Regulation of TSPO Gene Expression -- 7. Response to Injury and Disease -- 7.1. TSPO as a Target for Diagnosis and Medical Interventions
- 7.2. TSPO and Inflammatory and Immune Response -- 7.3. TSPO and Pathological Cardiovascular Conditions -- 7.4. TSPO and Cancer -- 7.5. TSPO and Anxiety and Stress -- 7.6. TSPO, Brain Injury, and Neurodegeneration -- 8. Maintenance of Homeostasis by TSPO at Cellular and Whole Organism Levels -- 9. Conclusion -- Conflict of Interest -- Acknowledgments -- References -- Further Reading -- Chapter Seven: Unique Effects of Clozapine: A Pharmacological Perspective -- 1. Introduction -- 2. History of Clozapine -- 3. Treatment-Resistant Schizophrenia -- 4. Suicidality -- 5. Substance Use in Schizophrenia -- 6. Basis of Substance Use Disorder in Schizophrenia -- 7. Pharmacology of Clozapine: Building a Safer Clozapine? -- 8. Conclusion -- Conflict of Interest -- Acknowledgments -- References -- Chapter Eight: Imaging Translocator Protein as a Biomarker of Neuroinflammation in Dementia -- 1. Introduction -- 2. Translocator Protein 18kDa -- 3. Radioligands for TSPO -- 4. Neuroinflammation in Alzheimer's Disease -- 5. Neuroinflammation in Non-Alzheimers Dementias -- 5.1. PDD and DLB -- 5.2. Frontotemporal Lobar Degeneration and Related Tauopathies -- 6. Alternative Targets for Neuroinflammation in Dementia -- 7. The Clinical Significance of Increased TSPO in Dementia -- 8. Conclusion -- Conflict of Interest Statement -- References -- Further Reading -- Chapter Nine: RNA-Based Fluorescent Biosensors for Detecting Metabolites in vitro and in Living Cells -- 1. Introduction -- 2. Organic Dye and Fluorescent Protein-Based Biosensors -- 3. Selective Molecular Recognition by Endogenous and Engineered RNAs -- 4. The First Engineered RNA-Based Metabolite Sensors -- 5. Fluorescent Biosensors Composed of RNA -- 6. Applications of Allosteric Spinach Sensors -- 7. RNA-Based Biosensors Modeled After Riboswitches -- 8. Conclusion -- Conflict of Interest -- Acknowledgments
- References -- Chapter Ten: Phosphorylation of the Amino Terminus of the Dopamine Transporter: Regulatory Mechanisms and Implications fo ... -- 1. Introduction -- 2. A Role for DAT N-Terminal Phosphorylation in DAT-Mediated DA Efflux -- 3. Kinases, Phosphatases, and Sites of Phosphorylation Implicated in DAT-Mediated DA Efflux -- 3.1. Ca2+/Calmodulin-Dependent Protein Kinase Alpha -- 3.2. Protein Kinase C -- 3.3. Phosphatases -- 3.4. Serine Residues -- 4. Regulation of DAT-Mediated DA Efflux by the Membrane Microenvironment -- 4.1. Flotillin-1 -- 4.2. Phosphatidylinositol 4,5-Bisphosphate -- 4.3. Syntaxin -- 5. Acute Action of AMPH at the VMAT -- 6. Conclusion -- Conflict of Interest -- Acknowledgments -- References -- Chapter Eleven: Anti-NMDA Receptor Encephalitis: Clinical Features and Basic Mechanisms -- 1. Introduction -- 2. NMDA Receptors -- 3. Anti-NMDAR Encephalitis -- 3.1. Essential Clinical Features -- 3.2. Relationship With Viral Infection -- 3.3. Treatment -- 4. Basic Mechanisms of Anti-NMDARE -- 4.1. NMDAR Antibodies From Other Human Disorders -- 4.2. Other Synaptic Encephalitides -- 5. NMDARE: A New Conceptualization -- 6. Conclusion -- Acknowledgments -- Conflict of Interest -- References -- Further Reading -- Chapter Twelve: Mu Opioid Pharmacology: 40 Years to the Promised Land -- 1. Introduction -- 2. Overview of Opioid Receptors -- 3. Mu Opioid Receptor Subtypes -- 4. Molecular Biology of Mu Opioid Receptors -- 5. Regional Expression of Oprm1 Variants in Naїve and Morphine Tolerant Mice -- 6. Full-Length Oprm1 Splice Variants and Biased Signaling -- 7. Pharmacological Characterization of Oprm1 Splice Variants -- 8. Pharmacological Characterization of C-Terminal Oprm1 Splice Variants -- 9. Chaperone Effects of 1TM Variants -- 10. 6TM and IBNtxA Pharmacology -- 11. Conclusion -- Conflict of Interest -- Acknowledgments -- References
- Chapter Thirteen: Synaptotoxic Signaling by Amyloid Beta Oligomers in Alzheimer's Disease Through Prion Protein and mGluR5 -- 1. Introduction -- 2. The Amyloid Hypothesis and Its Critiques -- 3. Soluble, Oligomeric Aβ Toxicity as Key to Amyloid Cascade Hypothesis -- 4. Mechanisms of Aβ Oligomer Toxicity at the Synapse -- 5. Neuronal Receptor as Central Mediator of Aβo Synapse Damage -- 6. Identification of PrPC as a Receptor for Aβo -- 7. Identification of mGluR5 as an Aβo Coreceptor -- 8. Aβo-Induced Disruption of the mGluR5-Homer1b/c-Pyk2-CamKII Complex -- 9. Targeting the Aβo-PrPC-mGluR5 Complex -- 10. Additional Receptors for Aβ: LilRB2, α7nAChR, and Others -- 11. Tau and Aβ in Concert: The Role of Fyn and Pyk2 -- 12. Aβ and Disrupted Homeostatic Equilibrium -- 13. Future Directions -- 14. Conclusion -- Conflict of Interest -- Acknowledgments -- References -- Chapter Fourteen: The Neurobiology of d-Serine Signaling -- 1. Introduction -- 2. d-Serine: From Worms to the Brain -- 3. Serine Racemase: A Multifunctional Enzyme -- 4. Neuronal vs Astroglial d-Serine -- 5. Physiological Roles of the Neuronal and Nonneuronal d-Serine -- 6. The Serine Shuttle -- 7. Regulation of d-Serine Signaling -- 8. d-Serine and Pathology -- 9. Conclusion -- Acknowledgments -- Conflict of Interests -- References -- Back Cover