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The physical microbe : an introduction to noise, control, and communication in the prokaryotic cell
- Author / Creator
- Available as
- Online
- Summary
-
Physical biology is a fusion of biology and physics. This book narrows down the scope of physical biology by focusing on the microbial cell; exploring the physical phenomena of noise, feedback, and...
Physical biology is a fusion of biology and physics. This book narrows down the scope of physical biology by focusing on the microbial cell; exploring the physical phenomena of noise, feedback, and variability that arise in the cellular information-processing circuits used by bacteria. It looks at the microbe from a physics perspective, asking how the cell optimizes its function to live within the constraints of physics. It introduces a physical and information-based (as opposed to microbiological) perspective on communication and signalling between microbes.
Details
- Creator
- Stephen J. Hagen
- Format
- Books
- Language
- English
- Publication
-
- San Rafael [California] (40 Oak Drive, San Rafael, CA, 94903, USA) : Morgan & Claypool Publishers, [2017]
- Bristol [England] (Temple Circus, Temple Way, Bristol BS1 6HG, UK) : IOP Publishing, [2017]
- Physical Details
-
- 1 PDF (various pagings) : illustrations (some color)
- data file
- ISBNs
- 9781681745299, 1681745291, 9781681745312, 1681745313, 9781681745282, 9781681745282
- OCLC
- on1012426598
- "Version: 20171001"--Title page verso.
- "A Morgan & Claypool publication as part of IOP Concise Physics"--Title page verso.
- Includes bibliographical references.
- Also available in print.
- Mode of access: World Wide Web.
- System requirements: Adobe Acrobat Reader, EPUB reader, or Kindle reader.
- Steve Hagen is Professor of Physics at the University of Florida. He began his scientific career in experimental condensed matter physics, studying high temperature superconductivity. He then switched to biological physics, studying first protein folding dynamics and then bacterial communication. Most recently his research work has focused on unravelling noisy regulatory pathways in quorum sensing bacteria. He has published numerous scientific papers in all of these areas, and he recently edited a book on the physics of bacterial communication.
- Preface : why the physical microbe? -- 1. Introduction -- 1.1. Diversity -- 1.2. Size -- 1.3. Energy -- 1.4. Food -- 1.5. Diffusion versus size
- 2. Growth -- 2.1. Exponential growth -- 2.2. Stationary phase -- 2.3. Lag phase and decline -- 2.4. Balanced growth -- 2.5. Partitioning of resources -- 2.6. Individual cells in balanced growth
- 3. Gene regulatory networks -- 3.1. Transcription and translation -- 3.2. Representation of networks and pathways -- 3.3. Gene regulation basics -- 3.4. Deterministic models for gene regulation
- 4. Stochastic gene expression -- 4.1. Variability at low copy number -- 4.2. Modeling stochastic expression -- 4.3. Bursts of gene expression -- 4.4. Protein distributions with both transcription and translation -- 4.5. Intrinsic and extrinsic noise -- 4.6. Noise reduction and stability through feedback
- 5. Phenotypic switching -- 5.1. Two types of persisters -- 5.2. Toxin-antitoxin systems and HipBA -- 5.3. Bet-hedging by phenotypic switching
- 6. Communication -- 6.1. Chemical communication -- 6.2. Pheromone triggered transitions of nonlinear systems -- 6.3. Electrical communication
- 7. Bacillus subtilis competence and sporulation : the final exam -- 7.1. Competence decision by noisy autofeedback -- 7.2. Phosphorelay sensor for sporulation -- 7.3. A mutually repressing circuit inhibits competence -- 7.4. Input from intercellular communication
Subjects
- Prokaryotes.
- Biophysics.
- Prokaryotic Cells
Medical Subject Heading
- Biophysics
Medical Subject Heading