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Current developments in biotechnology and bioengineering : functional genomics and metabolic engineering
- Available as
- Online
Details
- Creator
- editors, Paramasamy Gunasekaran, Santosh Noronha, Ashok Pandey
- Format
- Books
- Language
- English
- Publication
-
- Amsterdam : Elsevier, 2016
- Physical Details
-
- 1 online resource (320 p.)
- ISBNs
- 9780444636782, 0444636781, 9780444636676, 9780444636676
- OCLC
- ocn959151069
- 4.3.5 Signaling Pathways Associated With Uptake
- Front Cover; Current Developments in Biotechnology and Bioengineering; Current Developments in Biotechnology and Bioengineering: Functional Genomics and Metabolic Engineering; Copyright; Contents; List of Contributors; About the Editors; Preface; 1 -- Functional Genomics; 1 -- Functional Epigenomics; 1.1 Introduction; 1.2 Chromatin: The Epigenetic Center; 1.3 The Epigenetic Machinery; 1.3.1 DNA Methylation; 1.3.2 Histone Modification; 1.3.3 Chromatin Remodeling; 1.3.4 Role of Noncoding RNA in Epigenetic Regulation; 1.4 Epigenetics in Diseases
- 1.4.1 Epigenetic Modifications in Autoimmune Diseases1.4.2 Epigenetic Modifications in Neurological Disorders; 1.4.3 Epigenetic Modifications in Cancer; 1.4.4 Role of Epigenetic Modification in Differentiation of T Cells; 1.5 Functional Epigenomics-The Definition; 1.6 Approaches to Reading the Alternate Genomic Code; 1.6.1 DNA Methylation Analysis; 1.6.2 DNA Methylation Analysis of the Genome; 1.6.3 Chromatin Immunoprecipitation; 1.6.4 Chromosome Conformation Capture; 1.6.5 Circularized Chromosome Conformation Capture; 1.7 Modern Methods to Manipulate the Epigenome; 1.7.1 CRISPR/Cas9 System
- 1.7.2 Transcriptional Activator-Like Effector System1.7.3 Optogenetics; 1.8 Conclusion; References; 2 -- Functional Metagenomics: Exploring Nature's Gold Mine; 2.1 Introduction; 2.2 A Two-Way Approach; 2.3 Metagenomic DNA Recovery; 2.4 Functional Metagenomics: Toward Community Understanding; 2.4.1 Through Archiving Environmental DNA as Libraries; 2.4.1.1 The Mammoth Task: Screening of the Library; 2.4.1.2 Activity-Based Screening; 2.4.1.3 Sequence-Based Screening; 2.4.1.4 The Enduring Issues; 2.4.2 Through Whole Metagenome Sequencing; 2.4.3 The Enduring Issues; 2.5 Major Discoveries
- 2.5.1 Products for Industrial Applications2.5.2 Products for Therapeutics; 2.5.3 Genes for Bioremediation; 2.6 Summary and Future Perspective; Acknowledgments; References; 3 -- Functional Genomics of the Extremophilic Bacteria and Archaea; 3.1 Introduction; 3.2 Comparative and Functional Genomics of Thermophilic Bacteria; 3.3 Comparative and Functional Genomics of Psychrophilic Bacteria; 3.4 Comparative and Functional Genomics of Acidophilic Bacteria; 3.5 Comparative and Functional Genomics of Alkaliphilic Bacteria; 3.6 Comparative and Functional Genomics of Radiation-Tolerant Bacteria
- 3.7 Functional Genomics Versus Traditional Gene-by-Gene Approach3.8 Comparative Genomics, Proteomics, and Metabolomics; 3.9 Conclusions; References; 4 -- Functional Genomics of Riboflavin Transport: Genes and Regulatory Mechanisms; 4.1 Introduction; 4.2 Chromosomal Location and Genome Organization of Riboflavin Transporters; 4.2.1 SLC52A1; 4.2.2 SLC52A2; 4.2.3 SLC52A3; 4.2.4 ATP-Binding Cassette, Subfamily G, Member 2; 4.3 Transport Mechanism and Regulation; 4.3.1 Tissue Distribution; 4.3.2 Structural Predictions; 4.3.3 Regulation; 4.3.4 Small RNA Studies