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Bayesian designs for phase I-II clinical trials
- Author / Creator
- Available as
- Physical
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- Creator
- Ying Yuan, The University of Texas, MD Anderson Cancer Center, Houston, Texas, USA; Hoang Q. Nguyen, The University of Texas, MD Anderson Cancer Center, Houston, Texas, USA; Peter F. Thall, The University of Texas, MD Anderson Cancer Center, Houston, Texas, USA
- Format
- Books
- Language
- English
- Contributors
- Publication
-
- Boca Raton : CRC Press,Taylor & Francis Group, 2016
- ©2016
- Physical Details
-
- xiv, 310 pages : illustrations ; 24 cm
- ISBNs
- 9781498709552, 1498709559
- OCLC
- ocn936350306
- Includes bibliographical references (pages 283-300) and index.
- Why conduct phase I-II trials? -- The phase I-II paradigm -- Establishing priors -- Efficacy-toxicity trade-off-based designs -- Designs with late-onset outcomes -- Utility-based designs -- Personalized dose finding -- Combination trials -- Optimizing molecularly targeted agents -- Optimizing doses in two cycles -- Optimizing dose and schedule -- Dealing with dropouts -- Optimizing intra-arterial tPA -- Optimizing sedative dose in preterm infants
Subjects
- Clinical trials -- Statistical methods.
- Drugs -- Testing -- Statistical methods.
- Bayesian statistical decision theory.
- Clinical Trials, Phase I as Topic.
Medical Subject Heading
- Clinical Trials, Phase II as Topic.
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- Statistics as Topic.
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- Bayes Theorem.
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