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Cardiovascular pharmacology : heart and circulation
- Available as
- Online
- Summary
-
Cardiovascular disease remains a major cause of death and disability in developed countries and, increasingly so, in the developing world. Presented in this volume of Advances in Pharmacology are s...
Cardiovascular disease remains a major cause of death and disability in developed countries and, increasingly so, in the developing world. Presented in this volume of Advances in Pharmacology are some of the most promising possibilities for treating large numbers of individuals afflicted with these conditions Contains up-to-date reviews of the most important emerging cardiovascular therapies written by world leaders in the field
Details
- Creator
- edited by Paul M. Vanhoutte
- Format
- Books
- Language
- English
- Contributors
- Publication
-
- 1st ed
- Amsterdam : Elsevier, 2010
- Physical Details
-
- 1 online resource (345 p.)
- ISBNs
- 0123849047, 0123849039, 9780123849038, 9786612879630, 1282879634, 9780123849045
- OCLC
- ocn694146480, ocn688999664
- Description based upon print version of record.
- Includes bibliographical references and index.
- English
- Cover; Cardiovascular Pharmacology: Heart and Circulation; Contents; Contributors; Foreword; The Ryanodine Receptor in Cardiac Physiology and Disease; I. Introduction; II. Ryanodine Receptors; III. Regulation of RyR2 in the Cardiac Response to b-adrenergic Receptor Activation; IV. RyR2 Dysfunction in Heart Disease; V. Conclusion; References; Neuregulin-1/ErbB Signaling and Chronic Heart Failure; I. Introduction; II. NRG-1 And Its Receptors; III. NRG-1/ErbB Signaling in the Heart; IV. NRG-1/ErbB Signaling and Chronic Heart Failure
- V. The Molecular Mechanisms Underlying the Effects of rhNRG-1Treatment on Heart FailureVI. Conclusion; References; If Inhibition in Cardiovascular Diseases; I. Introduction; II. Role of If in Cardiac Pacemaking; III. Pharmacology of If Inhibitors; IV. In Vivo Preclinical Studies; V. Clinical Studies; VI. Conclusion; References; Pharmacology of Cardiac Potassium Channels; I. Introduction; II. K+ Channel Classification; III. Cardiac Voltage-Gated K+ Channels; IV. Inward Rectifier K+ Currents; V. Cardiac Two Pore K+ Current K2P; VI. Conclusion; References
- Beta3-Adrenergic Receptors in Cardiacand Vascular Tissues: Emerging Conceptsand Therapeutic PerspectivesI. Introduction; II. Molecular Structure of Beta3-AR; III. Pharmacologic Properties of Beta3-AR; IV. Beta3-AR in the Cardiac Muscle; V. Vascular Beta3-ARs; VI. Clinical Perspectives; VII. Conclusion; References; Modulation of Vascular Sarco/Endoplasmic Reticulum Calcium ATPase in Cardiovascular Pathophysiology; I. Introduction; II. Mechanism of cGMP-Independent Relaxation to NO; III. Oxidative Stress, NO Bioactivity, and Vascular Physiology/Pathophysiology
- IV. Posttranslational Oxidative Modifications of SERCAV. Physiological and Pathophysio logical Rolesof Thiol Modifications on SERCA in NO-Induced Relaxation; VI. Other Diseases Related with the Inactivation of SERCA; VII. Conclusion; References; Advances in the Renin Angiotensin System: Focus on Angiotensin-Converting Enzyme 2 and Angiotensin-(1-7); I. Introduction; II. The Paradigm Shift; III. The ACE2/Ang-(1-7)/Mas Axis; IV. Angiotensin-Converting Enzyme 2 as a Component of the Ang-(1-7)/Mas Axis; V. The Ang-(1-7)/ACE2/Mas-R Axis in the Regulation of Pregnancy; VI. Conclusion; References
- The Role of Calpain in Diabetes-Associated Platelet HyperactivationI. Introduction; II. Calpains and the Development of Diabetes; III. Role of Calpain in the Diabetes-Associated Platelet Hyperactivation; IV. Effect of Antidiabetics on Calpain Function; V. Conclusion: Calpain as a Platelet Drug Target?; References; Tissue Factor in Cardiovascular Disease: Pathophysiology and Pharmacological Intervention; I. Introduction; II. TF: Structure and Function; III. TF in Cardiovascular Disease; IV. Therapeutic Implications; V. Conclusion; References; Index; Contents of Previous Volumes