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Progress in medicinal chemistry 48
- Available as
- Online
- Summary
-
Progress in Medicinal Chemistry provides a review of eclectic developments in medicinal chemistry. This volume continues in the serial's tradition of providing an insight into the skills required o...
Progress in Medicinal Chemistry provides a review of eclectic developments in medicinal chemistry. This volume continues in the serial's tradition of providing an insight into the skills required of the modern medicinal chemist; in particular, the use of an appropriate selection of the wide range of tools now available to solve key scientific problems. *Presents the latest research in the field of drug discovery *Publishes on a twice yearly basis to bring you the most innovative updates in medicinal chemistry *Available as an online resource via ScienceDirect
Details
- Creator
- editors, G. Lawton and D.R. Witty
- Format
- Books
- Language
- English
- Contributors
- Publication
-
- 1st ed
- Netherlands : Elsevier, 2009
- Physical Details
-
- 1 online resource (258 p.)
- ISBNs
- 9786612618604, 9780080950860, 1282618601, 0080950868, 9780444533586, 0444533583
- OCLC
- ocn801653828, ocn649907750
- Description based upon print version of record.
- Includes bibliographical references and indexes.
- English
- Front Cover; Progress in Medicinal Chemistry 48; Copyright Page; Contents; Preface; List of Contributors; Chapter 1 Medicinal Chemistry by the Numbers: The Physicochemistry, Thermodynamics and Kinetics of Modern Drug Design; INTRODUCTION; PHYSICOCHEMISTRY; SHAPE; BINDING; BINDING KINETICS; CONCLUSIONS; REFERENCES; Chapter 2 The Identification of and Rationale for Drugs Which Act at The Motilin Receptor; INTRODUCTION; ADVANCES IN MOTILIN RECEPTOR NEUROPHARMACOLOGY; MOTILIN RECEPTOR AGONISTS; MOTILIN RECEPTOR ANTAGONISTS; CONCLUSIONS; REFERENCES
- Chapter 3 Progress in the Design and Development of Phosphoinositide 3-Kinase (PI3K) Inhibitors for the Treatment of Chronic DiseasesINTRODUCTION; THE PHOSPHOINOSITIDE 3-KINASE (PI3K) FAMILY; THE PI3K SIGNALLING PATHWAY: DOWN-STREAM TARGETS AND FUNCTIONS; TARGETING PI3Ks: THERAPEUTIC POTENTIAL OF SMALL MOLECULE INHIBITORS; CLINICAL LANDSCAPE; FUTURE PERSPECTIVE; REFERENCES; Chapter 4 Progress in the Development of β-secretase Inhibitors for Alzheimer's Disease; INTRODUCTION; ASTEX; ASTEX/ASTRAZENECA; GSK; HOFFMANN-LA ROCHE; JOHNSON AND JOHNSON; MERCK; NOVARTIS; PFIZER; SCHERING-PLOUGH
- SUNESISWYETH; SUMMARY; REFERENCES; Chapter 5 Advances in the Design of 5-HT[sub(6)] Receptor Ligands with Therapeutic Potential; INTRODUCTION; MEDICINAL CHEMISTRY OF 5-HT[sub(6)] RECEPTOR MODULATION; CLINICAL ACTIVITIES; CONCLUSION; REFERENCES; Subject Index; A; B; C; D; E; F; G; H; I; J; K; L; M; N; O; P; Q; R; S; T; V; W; Cumulative Index of Authors for Volumes 1-48; A; B; C; D; E; F; G; H; I; J; K; L; M; N; O; P; R; S; T; U; V; W; Y; Z; Cumulative Index of Subjects for Volumes 1-48; A; B; C; D; E; F; G; H; I; K; L; M; N; O; P; Q; R; S; T; U; V