Website Search
Find information on spaces, staff, and services.
Catalog Search
Books
Bioorganometallics biomolecules, labeling, medicine
- Available as
- Online
- Physical
- Summary
-
This first comprehensive book to cover the expanding field of bioorganometallics represents the perfect starting point for beginners but also an excellent source of high quality information for exp...
This first comprehensive book to cover the expanding field of bioorganometallics represents the perfect starting point for beginners but also an excellent source of high quality information for experts in the field.Edited by a pioneer in the field with an excellent standing within the community, this book begins with the history of bioorganometallics, before going on to cover pharmaceuticals, bioorganometallic chemistry and radiopharmaceuticals.A must for bioinorganic chemists, the pharmaceutical industry, chemists working in organometallics and biochemists.
Details
Checking for availability...
- Creator
- edited by Gérard Jaouen
- Format
- Books
- Language
- English
- Contributors
- Publication
-
- Weinheim : Wiley-VCH, c2006
- Physical Details
-
- 1 online resource (464 p.)
- ISBNs
- 3527607110, 3527607692, 9783527607693, 9783527309900, 9786610854196, 352730990X, 1280854197, 9783527607112
- OCLC
- ocm85821090, ocm62362280, ocm70054383
- Description based upon print version of record.
- Includes bibliographical references and index.
- English
- Bioorganometallics; Preface; Contents; List of Contributors; 1 A Novel Field of Research: Bioorganometallic Chemistry, Origins, and Founding Principles; 1.1 Introduction; 1.2 Organometallics and Therapy; 1.2.1 The Founding Father; 1.2.2 The First Significant Organometallic Drug; 1.2.3 Arsenic Compounds after Ehrlich; 1.2.4 Organometallic Mercury Compounds; 1.2.5 The Current Re-evaluation: Considerations of Efficacy, Toxicity and Selectivity; 1.3 Toxicology and the Environment; 1.4 Bioanalytical Methods Based on Special Properties of Organometallic Complexes
- 1.5 Naturally-occurring Organometallics and Synthetic Models1.6 Organometallic Chemistry and Aqueous Solvents; 1.7 Conclusions; References; 2 Ruthenium Arene Anticancer Complexes; 2.1 Introduction; 2.2 Metal-based Anticancer Complexes; 2.3 Chemistry of Ru Arenes; 2.3.1 Synthesis; 2.3.2 Structure; 2.3.3 Chirality; 2.4 Biological Activity; 2.4.1 Antibacterial; 2.4.2 Anticancer; 2.4.3 Biodistribution and Metabolism; 2.5 Mechanism of Action; 2.5.1 Nucleobase and DNA Binding; 2.5.2 Amino Acids and Proteins; 2.5.3 Aquation; 2.6 Conclusions; References
- 3 Organometallics Targeted to Specific Biological Sites: the Development of New Therapies3.1 Introduction; 3.2 Overview of Previous Developments; 3.3 Metal Complex SERMs (Selective Estrogen Receptor Modulators); 3.3.1 Inorganic Complexes of Platinum; 3.3.2 Carborane Derivatives with Estrogenic Properties; 3.3.3 Titanocene Dichloride Derivative of Tamoxifen; 3.3.4 Cyclopentadienyl Rhenium Tricarbonyl Derivatives of Tamoxifen Derivatives; 3.3.5 Ferrocene Tamoxifen Derivatives (Ferrocifens); 3.3.6 Ruthenocene Tamoxifen Derivatives; 3.3.7 Conclusion for SERMs
- 3.4 The Alkyne Cobalt Carbonyl Complexes3.5 Ferroquine, a New Weapon in the Fight Against Malaria: the Archetypical Bioorganometallic Approach; 3.5.1 The Problem of Malaria; 3.5.2 Ferroquine: a Bioorganometallic Approach; 3.5.3 Conclusion for Ferroquine; 3.6 Other Examples of Organometallics Complexes Tested for their Biological Activities; 3.7 Conclusions; References; 4 Radiopharmaceuticals; 4.1 What are Radiopharmaceuticals?; 4.1.1 Radiopharmaceutical Drug Finding and Drug Development; 4.1.2 Organometallic Complexes in Radiopharmaceutical Routines; 4.2 Organometallic Aquo-ions
- 4.3 The Prototype [(99)Tc(OH(2))(3)(CO)(3)](+), Synthesis and Properties4.3.1 Coordination Chemistry with [(99)Tc(OH(2))(3)(CO)(3)](+); 4.3.2 Organometallic Chemistry in Water with [(99)Tc(OH(2))(3)(CO)(3)](+); 4.4 Combining [(99)Tc(OH(2))(3)(CO)(3)](+) with Targeting Vectors; 4.5 Perspectives; References; 5 Conjugates of Peptides and PNA with Organometallic Complexes: Syntheses and Applications; 5.1 Introduction; 5.2 Conjugates of Organometallics with Small Peptides; 5.2.1 Organometallics as Templates for the Induction of Secondary Structural Elements in Peptides
- 5.2.1.1 Derivatives of 1,1'-Ferrocene Dicarboxylic Acid