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Adaptive design methods in clinical trails
- Author / Creator
- Available as
- Physical
- Summary
-
"One of the first books on the topic, Adaptive Design Methods in Clinical Trials presents the principles and methodologies in adaptive design and analysis the pertain to adaptations made to trial o...
"One of the first books on the topic, Adaptive Design Methods in Clinical Trials presents the principles and methodologies in adaptive design and analysis the pertain to adaptations made to trial or statistical procedures that are based on accrued data of ongoing clinical trials. The book also offers a well-balanced summary of current regulatory perspectives and recently developed statistical methods in this area."--BOOK JACKET.
Details
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- Creator
- Shein-Chung Chow, Mark Chang
- Format
- Books
- Language
- English
- Contributors
- Publication
-
- Boca Raton, FL : Chapman & Hall/CRC, [2007]
- ©2007
- Physical Details
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- 277 pages : illustrations ; 24 cm
- ISBNs
- 1584887761, 9781584887768
- OCLC
- ocm70408042
- Includes bibliographical references (pages [255]-267) and index.
- 1. Introduction -- 2. Protocol amendment -- 3. Adaptive randomization -- 4. Adaptive hypotheses -- 5. Adaptive dose-escalation trials -- 6. Adaptive group sequential design -- 7. Adaptive sample size adjustment -- 8. Adaptive seamless phase II/III designs -- 9. Adaptive treatment switching -- 10. Bayesian approach -- 11. Clinical trial simulation -- 12. Case studies
Subjects
- Clinical trials.
- Adaptive sampling (Statistics)
- Experimental design.
- Clinical trials -- Statistical methods.
- Clinical Trials as Topic -- methods.
Medical Subject Heading
- Research Design.
Medical Subject Heading
- Biometry -- methods.
Medical Subject Heading
- Models, Statistical.
Medical Subject Heading