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Prenatal gene therapy : concepts, methods, and protocols
- Available as
- Online
- Physical
Details
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- Creator
- edited by Charles Coutelle, Simon N. Waddington
- Format
- Books
- Language
- English
- Contributors
- Publication
-
- Totowa, NJ : Humana Press, [2012]
- ©2012
- Physical Details
-
- x, 392 pages : illustrations ; 27 cm
- ISBNs
- 1617798738, 9781617798726, 9781617798733, 161779872X
- OCLC
- ocn795128302, ocn805233967
- Includes bibliographical references and index.
- The concept of prenatal gene therapy -- Candidate diseases for prenatal gene therapy -- Vector systems for prenatal gene therapy: Choosing vectors for different applications -- Vector systems for prenatal gene therapy: Principles of adenovirus design and production -- Vector systems for prenatal gene therapy: Principles of retrovirus vector design and production -- Vector systems for prenatal gene therapy: Principles of adeno-associated virus vector design and production -- Vector systems for prenatal gene therapy: Principles of non-viral vector design and production -- Use of manipulated stem cells for prenatal therapy -- Animal models for prenatal gene therapy: Choosing the right model -- Animal models for prenatal gene therapy: Rodent models for prenatal gene therapy -- Animal models for prenatal gene therapy: The sheep model -- Animal models for prenatal gene therapy: The nonhuman primate model -- Choice of surrogate and physiological markers for prenatal gene therapy -- Monitoring for potential adverse effects of prenatal gene therapy: Use of large animal models with relevance to human application -- Monitoring for potential adverse effects of prenatal gene therapy: Mouse models for developmental aberrations and inadvertent germ line transmission -- Monitoring for potential adverse effects of prenatal gene therapy: Genotoxicity analysis in vitro and on small animal models ex vivo and in vivo -- Risks, benefits and ethical, legal, and societal considerations for translation of prenatal gene therapy to human application