THE UUIVERSITY OF MIiiSOT: 
TH   EDICIL SChCOOI 
MIINJPOLIS. 
February 21, 1928. 
Mr. Albert C. Klancke, 
Isst. Commissioner of (lame ndFish, 
St. Enul, Linn. 
Dear 1r. Klanoke: 
Thls letter is in reply to yours of 
February 18th,  'hen I suggested that the eprtnent su  ly me 
with prairie hckens and H-ngripn partridges for testing their 
susceptibility to tularemia, I did not realize that these blirs 
woulA have to be trappea.   ',ot understanding the situation I sup- 
posed there were some available in small yards at the game farm, 
and thqt some extra males might be utllized in tise work. I also 
do not consider it necessay to tske for this purose Hungrian 
partridges w     14ch hve beetI liberated. If it seems of sufficient 
importance to you, however, I would be glad to test out the sue- 
ceptibility of praIrie chickens to this dIsesse,   If they qre found 
to besusceptible, this Information will be furnished to Dr. H.?. 
Pnr',er, of the Tnited States Public Health  ervi e Laboratory at 
hamilton, o:It., and he would then carry out experiements in the 
natural transuission of thlis disese to prairle chickens by menr s 
of infe stive ticks. 
. ..... ..e. p.r.it     giv n  me  for 
tkling ruffed grouse three have been taken to dnte. One of tlhese 
wfs given an intramuscular injection of the bacillus tulqrense from 
one of the human oases of tularemia ocurrilng in Linnesota last 
sumer. The p-rtridge ws taken nes Park Epids where the case 
occurred. The blood of the partridge was examined for imiune bodies 
against bacillus tularense, previous to the injection, and the in- 
dications were that this particular partridge had never had a tula- 
remlo Infection. This partridge died on the thlird dy folloriing its 
Inooul-tioi, and organisr-s were obtained from four dif-erent rcgions 
of its body, Ihowing that bacillus tularense had produced the dis- 
ease in the pnrtridge  The second partridge was inoculated vith 
a small dose subcutaneously. Although this partri;dge is spparently 
ill with the  isease, it is still alive on the third dy.     The 
third partridge taken I have eb ped to the spotted 'ever T.Pbora- 
tory, at Hamilton, Mont., for Dr. Parker to attempt infection by 
means of an Infective tick.   I vould like to ship Dr.   rker at 
least two more ruffed grouse for his part of the experiments. 
I am eytreielv- interested in bacillus 
tularense from a bacteriolog-icl viewpoint. It is very peculiar 
in that it is able to produce infection in  uch wiely divergent 
groups of animals. Its power of produlin dsese seems to be great- 
ly modified by the anim.l in which it resides.   The organs  com- 
ing from qhumgn being is apparently only slightly pathogenic for 
other human bellngs. Coming from rabbits it is very psthogenlc for 
human beIngs. I wish to fina out what its proferties are when 
coming from birds. 
I trust my interest In thi- ir.-ter has 
the approval of the Department,  nd  I will be more tr-an glad if 
any Information I obtain will be some of sone value. 
Very truly -ours, 
 
Sig ned