8The Atlantic Seaboard


proteins would also sensitize, that an incubation period of several days
between the sensitizing and shocking dose was necessary, that the off-
spring of sensitized mothers were also hypersensitive, and that guinea
pigs may be sensitized by feeding were all brought out by their studies,
which were highly important in the history of these complex phe-
nomena.
   Since anaphylactic shock in guinea pigs is frequently referred to as
the "Theobald Smith Phenomenon" because of the title of Otto's
illu-
minating studies (1905 and 1907), I am giving Smith's only published
reference to the reaction in an abstract of discussion following one of
the Rosenau and Anderson papers before the American Medical As-
sociation in 19o6. Smith stated that he had been interested in the phe-
nomenon since 1902, but had made no special effort to analyze it. In his
sample experiment given in a table, he allowed an interval of only 2-3
minutes between the first and second injections and used 3-5 cc. vol-
umes in each injection. A small percentage of Smith's animals died
(neither symptoms nor autopsy findings described in the abstract);
actually a larger percentage of his controls that had not received the
primary injection died than in the group that had received such injec-
tions. Possibly the serum was toxic in such doses. At any rate, informed
persons would agree that, in these experiments, Smith was not dealing
with anaphylactic shock or allergy, making apparent the confusion
existing at that time.
   In 1909 Rosenau accepted the chair of preventive medicine and hy-
 giene in Harvard Medical School, a position he held until he reached
 the age of retirement in 1935-.A highly important contribution was his
 Preventive Medicine and Hygiene, the first edition in 1913, continued
 through six editions under his hand; now it is in the eighth edition with
 many authors under the editorship of K. F. Maxcy. No one had pro-
 duced so readable, arresting, authoritative a volume full of personal
 experience, invaluable to all persons studying, teaching, and working in
 the fields. A sanitary survey of a city or town, which he emphasized as
 an excellent method of learning, for each medical student, has been
 used profitably by several institutions. During much of this period
 (1913-2 z), Rosenau was also active in organizing and in teaching in
 the Harvard-Massachusetts Institute of Technology School for Health
 Officers. During the decade this school rendered excellent service.
    In experimental contributions, Rosenau's most important work in
  his Harvard period was, I believe, a continuation of his studies on al-


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