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Quantitative Gas Chromatography-Mass Spectrometry in the Life Sciences : Principles and Bioanalytical Applications
- Author / Creator
- Available as
- Online
- Summary
-
Quantitative Gas Chromatography-Mass Spectrometry: Principles in Life Sciences and Biochemical Applications provides an in-depth exploration of the principles and practices of GC-MS.
Details
- Creator
- Dimitrios Tsikas
- Format
- Books
- Language
- English
- Publication
-
- 1st ed
- Amsterdam, Netherlands : Elsevier, [2026]
- ©2026
- Physical Details
-
- 1 online resource (1016 pages)
- ISBNs
- 9780443300974, 0443300976, 0443300968
- OCLC
- on1559217718
- Includes bibliographical references and index.
- Front Cover -- Quantitative Gas Chromatography-Mass Spectrometry in the Life Sciences: Principles and Bioanalytical Applications -- Copyright Page -- Dedication -- Contents -- Preface -- References -- Further reading -- Acknowledgments -- 1 Principles of quantitative analysis by gas chromatography-mass spectrometry, triple quadrupole gas chromatography-mass spectrometry, and high-resolution mass spectrometry coupled to gas chromatography -- 1.1 Introduction to analytical chemistry -- 1.1.1 Etymological issues -- 1.1.2 Classical and modern analytical chemistry -- 1.1.3 Short history of instrumental chemical analysis -- 1.1.4 Chemistry and alchemy -- 1.2 Introduction to quantitative analysis by gas chromatography-mass spectrometry and triple quadrupole gas chromatography-mass spectrometry -- 1.2.1 A brief historical retrospect -- Internet databases -- 1.2.2 An example of an early qualitative and quantitative analytical chemistry -- 1.3 Quadrupole-based gas chromatography-mass spectrometry and triple quadrupole gas chromatography-mass spectrometry -- 1.3.1 General aspects -- 1.3.2 Quadrupole-based gas chromatography-mass spectrometry and triple quadrupole gas chromatography-mass spectrometry -- 1.3.2.1 Composition and set-up -- 1.3.2.2 Basic principle of quadrupole mass spectrometry -- 1.3.2.3 Tuning/mass calibration of gas chromatography-mass spectrometry and triple quadrupole gas chromatography-mass spectrometry instruments -- 1.3.2.4 Mass spectra and chromatograms-definitions and examples -- 1.4 Quantitative gas chromatography-mass spectrometry and triple quadrupole gas chromatography-mass spectrometry analysis-SIM and SRM -- 1.5 Quantitative high-resolution mass spectrometry coupled to gas chromatography -- 1.5.1 Introduction -- 1.5.2 Examples of the use of high-resolution mass spectrometry coupled to gas chromatography in quantitative analyses
- 1.5.2.1 Quantitation of adrenaline and noradrenaline from human plasma -- 1.5.2.2 Quantitative determination of prostaglandins and thromboxane B2 by high-resolution mass spectrometry coupled to gas chromatography -- 1.5.2.3 Quantitative determination of the beta-blocker carteolol in human plasma high-resolution mass spectrometry coupled to gas chromatography -- 1.5.2.4 Quantitative high-resolution mass spectrometry coupled to gas chromatography in doping control -- 1.5.2.5 Quantitative high-resolution mass spectrometry coupled to gas chromatography in drug of abuse -- 1.5.3 Triple quadrupole gas chromatography-mass spectrometry and high-resolution mass spectrometry coupled to gas chromatography of testosterone and precursors -- 1.5.4 Mutagenesis and carcinogenesis agent propylene oxide -- 1.5.5 High-resolution mass spectrometry coupled to gas chromatography in the environmental and epidemiological sciences -- 1.5.6 Comparison of high-resolution mass spectrometry coupled to gas chromatography and triple quadrupole gas chromatography-mass spectrometry -- 1.6 Evaluation of the analytical performance -- 1.6.1 Introduction -- 1.6.2 Definitions and formulas -- 1.6.2.1 Precision and accuracy -- 1.6.2.2 Limits of detection and quantitation -- 1.6.2.3 Acceptance criteria for precision and accuracy -- 1.6.3 Examples of the determination of LLOQ and rLLOQ -- 1.6.3.1 Asymmetric dimethylarginine -- 1.6.3.2 Stable-isotope labeled analogs of endogenous compounds -- 1.6.3.3 Examples of LLOQ and rLLOQ in gas chromatography-mass spectrometry and triple quadrupole gas chromatography-mass spectrometry -- 1.6.4 Supplementary information -- 1.7 Comparison of quantitative analytical methods -- 1.7.1 Introduction -- 1.7.2 Comparison of gas chromatography-mass spectrometry and triple quadrupole gas chromatography-mass spectrometry methods for homoarginine in human plasma
- 1.8 Development and validation of quantitative gas chromatography-mass spectrometry and triple quadrupole gas chromatography-mass spectrometry methods -- 1.8.1 Introduction -- 1.8.2 Pre-analytics, study design, ethics -- 1.8.3 Analytics - specific information -- 1.8.4 Issues for consideration in development of bioanalytical gas chromatography-mass spectrometry methods -- 1.8.5 Issues for consideration in validation of bioanalytical gas chromatography-mass spectrometry methods -- 1.8.6 Bioanalytical applications and publication of new gas chromatography-mass spectrometry methods -- 1.8.7 Anandamide -- 1.8.7.1 Background, biological sample, concentration range, requirements -- 1.8.7.2 Method development -- 1.8.7.3 Method validation -- 1.8.7.4 Method application -- 1.8.8 Dimethylamine -- 1.8.8.1 Background, biological samples, concentration ranges, requirements -- 1.8.8.2 Method development -- 1.8.8.3 Method validation -- 1.8.8.4 Method application -- 1.8.9 Summary -- 1.9 Ethics in analytical chemistry -- 1.9.1 S-Nitrosoalbumin and other S-nitrosothiols -- 1.9.2 S-Nitrosoglutathione and blood pressure -- 1.9.3 Nitro fatty acids -- 1.9.4 Concluding remarks -- 1.10 Health and disease from an analytical perspective -- 1.10.1 Introduction -- 1.10.1.1 Clinical chemistry -- 1.10.1.2 Academical analytical chemistry -- 1.10.1.3 Health and disease from the analytical chemistry perspective -- 1.10.1.4 Examples of the contribution of analytical chemistry in medicine: DMA and ADMA -- 1.10.2 Clinical trials -- 1.10.2.1 Examples of applications of gas chromatography-mass spectrometry and triple quadrupole gas chromatography-mass spectrometry in clinical studies -- Synopsis -- 1.10.2.1.1 Results of the PAOD and CAD studies -- Clinical parameters -- Biochemical parameters -- 1.10.2.2 Pre-analytical factors in clinical studies
- 1.10.2.2.1 Time point of quantitative gas chromatography-mass spectrometry and triple quadrupole gas chromatography-mass spectrometry analysis -- 1.10.2.2.2 Effects of randomization -- 1.10.2.2.3 Blood sampling - type of anti-coagulation and hemolysis -- 1.10.2.2.4 Urine collection -- 1.10.2.2.5 Plasma or urine for biomarkers of oxidative stress? -- 1.10.2.2.6 Hemolysis -- 1.10.2.2.7 Effects of drugs -- 1.10.2.2.8 Circadian rhythmicity -- 1.10.2.2.9 Quality control -- 1.10.3 Summary -- 1.10.4 Examples of establishing reference values/intervals -- 1.10.4.1 Amino acids -- 1.10.4.2 Asymmetric dimethylarginine -- 1.10.4.3 Asymmetric dimethylarginine, symmetric dimethylarginine, homoarginine -- 1.10.4.3.1 Results -- 1.10.4.4 Homoarginine (hArg) -- 1.10.4.4.1 Results -- 1.10.4.5 Creatinine -- 1.11 Selection of gas chromatography-mass spectrometry instruments and columns used in the chapter -- 1.12 Gas chromatography-mass spectrometry in space -- References -- Further reading -- 2 Extraction and analytical derivatization techniques in GC-MS -- 2.1 Extraction and analytical derivatization techniques in GC-MS -- 2.1.1 Extraction techniques in GC-MS -- 2.1.1.1 General aspects -- 2.1.1.2 Liquid-liquid extraction -- 2.1.1.3 Solid-phase extraction -- 2.1.1.3.1 Solid-phase extraction using phenylboronic acid chromatography -- 2.1.1.3.2 Immunoaffinity column chromatography -- 2.1.1.3.3 Extraction after derivatization -- 2.1.1.4 Chemoafffinity chromatography -- 2.1.1.5 Automated extraction as sample preparation for GC-MS analysis -- 2.1.1.6 Summary -- 2.2 Derivatization techniques in GC-MS -- 2.2.1 Derivatization with pentafluorobenzyl bromide for quantitative GC-MS -- 2.2.1.1 General remarks -- 2.2.1.2 Individual analytes -- 2.2.1.3 Derivatization and analysis of inorganic anions -- 2.2.1.4 Stable-isotope labeled inorganic anions in PFB-Br derivatization
- 2.2.1.5 Derivatization and analysis of organophosphates -- 2.2.1.6 Summary -- 2.2.2 Microscale analytical derivatizations on solid-phase -- 2.2.2.1 Introduction -- 2.2.2.2 Applications -- 2.2.2.3 Summary -- 2.2.3 Analytical derivatization in environmental analysis -- 2.2.3.1 Introduction -- 2.2.3.2 In situ derivatization -- 2.2.3.3 In-port derivatization -- 2.2.3.4 Solid-phase analytical derivatization -- 2.2.3.5 Ultrasound-assisted derivatization -- 2.2.3.6 Microfluidic lab-on-a-chip derivatization -- 2.2.4 GC-MS analysis of nitrite in biological fluids without derivatization -- 2.2.4.1 Introduction -- 2.2.4.2 Results and discussion -- 2.2.4.3 Summary -- 2.2.5 Quantitative GC-MS analysis of S-nitrosothiols by in-injector nitrosation -- 2.2.5.1 Introduction -- 2.2.5.2 Results -- 2.2.5.3 Discussion -- 2.3 Selection of GC-MS instruments and GC columns used in the chapter -- References -- Further reading -- 3 Quantitative GC-MS analysis of amino acids -- 3.1 Introduction to amino acids, peptides, and proteins -- 3.1.1 Derivatization of amino acids for GC-MS analysis -- 3.1.2 Structure of the chapter -- 3.2 GC-MS analysis of arginine and its amino acid metabolites -- 3.2.1 Introduction -- 3.2.2 GC-MS analysis of arginine and its metabolites as methyl ester pentafluoropropionyl derivatives -- 3.2.3 GC-MS analysis of homoarginine -- 3.2.4 GC-MS analysis of asymmetric dimethylarginine and symmetric dimethylarginine -- 3.2.5 GC-MS analysis of guanidinoacetate -- 3.2.5.1 GC-MS analysis of guanidinoacetate as methyl ester pentafluoropropionyl derivative -- 3.2.5.2 GC-MS analysis of guanidinoacetate as pentafluorobenzyl ester derivative -- 3.2.6 GC-MS analysis of NG-hydroxyarginine -- 3.3 GC-MS analysis of ornithine, lysine, citrulline, and homocitrulline -- 3.3.1 Introduction
- 3.3.2 GC-MS analysis of ornithine and citrulline as methyl ester pentafluoropropionyl derivatives
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